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  1. Fulltext Impacts of Curcumin Supplementation on Cardiometabolic Risk Factors in Patients With Polycystic Ovary Syndrome: A Systematic Review and Dose-Response Meta-Analysis
    Mohammadi S, Ziaei S, Morvaridi M, Hasani M, Mirtaheri E, Farsi F, et al.
    Health Sci Rep, 2025 Mar;8(3):e70525.
    PMID: 40041784 DOI: 10.1002/hsr2.70525
    BACKGROUND AND AIM: Patients with polycystic ovary syndrome (PCOS) commonly have cardiometabolic risk factors. Oxidative stress (OS) significantly contributes to the development of cardiometabolic diseases. Curcumin (CUR) exhibits antioxidant properties that aid in OS regulation. This systematic review and dose-response meta-analysis of randomized clinical trials (RCTs) evaluated the effects of CUR supplementation on cardiometabolic risk factors in women with PCOS.

    METHODS: A systematic search across various databases was implemented to identify eligible RCTs published until January 2024. A meta-analysis was conducted employing a random-effects model.

    RESULTS: Eight RCTs were included in the meta-analysis. It was indicated that CUR supplementation substantially reduced fasting blood sugar (FBS) (standardized mean difference [SMD]: -0.40 mg/dL, 95% confidence interval [CI]: -0.59, -0.21; p 

  2. Fulltext Does supplementation with pine bark extract improve cardiometabolic risk factors? A systematic review and meta-analysis
    Mohammadi S, Fulop T, Khalil A, Ebrahimi S, Hasani M, Ziaei S, et al.
    BMC Complement Med Ther, 2025 Feb 22;25(1):71.
    PMID: 39987124 DOI: 10.1186/s12906-025-04819-9
    BACKGROUND: Supplementation with pine bark extract (PBE) may improve risk factors associated with cardiometabolic syndrome (CMS). The effects of PBE supplementation on cardiometabolic risk factors were evaluated in this systematic review and meta-analysis of randomized controlled trials (RCTs).

    METHODS: A comprehensive search of various databases was performed to identify relevant RCTs published up to September 2024. A random-effects model was employed for the meta-analysis, which included 27 RCTs with 1,685 participants.

    RESULTS: The findings indicated that PBE supplementation significantly reduced systolic blood pressure (SBP) (weighted mean difference (WMD): -2.26 mmHg, 95% confidence interval (CI): -3.73, -0.79; P = 0.003), diastolic blood pressure (DBP) (WMD: -2.62 mmHg, 95% CI: -3.71, -1.53; P 

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