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Does supplementation with pine bark extract improve cardiometabolic risk factors? A systematic review and meta-analysis

Mohammadi S 1 , Fulop T 2 , Khalil A 2 , Ebrahimi S 3 , Hasani M 4 , Ziaei S 5 Show all authors , Farsi F 6 , Mirtaheri E 7 , Afsharianfar M 8 , Heshmati J 9

Affiliations 

  • 1 Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 6135715794, Iran. shooka.mohammadi@gmail.com
  • 2 Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada
  • 3 The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia
  • 4 Department of Nutritional Sciences, School of Health, Golestan University of Medical Sciences, Gorgan, Iran
  • 5 Department of Anesthesia, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 6 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  • 7 Department of Biochemistry and Dietetics, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  • 8 Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  • 9 Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran. javad.heshmati@gmail.com
BMC Complement Med Ther, 2025 Feb 22;25(1):71.
PMID: 39987124 DOI: 10.1186/s12906-025-04819-9

Abstract

BACKGROUND: Supplementation with pine bark extract (PBE) may improve risk factors associated with cardiometabolic syndrome (CMS). The effects of PBE supplementation on cardiometabolic risk factors were evaluated in this systematic review and meta-analysis of randomized controlled trials (RCTs).

METHODS: A comprehensive search of various databases was performed to identify relevant RCTs published up to September 2024. A random-effects model was employed for the meta-analysis, which included 27 RCTs with 1,685 participants.

RESULTS: The findings indicated that PBE supplementation significantly reduced systolic blood pressure (SBP) (weighted mean difference (WMD): -2.26 mmHg, 95% confidence interval (CI): -3.73, -0.79; P = 0.003), diastolic blood pressure (DBP) (WMD: -2.62 mmHg, 95% CI: -3.71, -1.53; P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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