MyMedR

Histomorphometric changes in the vessel wall at the site of amputation in diabetic patients--do they influence healing of the stump?

Naidu SV, Sengupta S

J Orthop Surg (Hong Kong), 2005 Apr;13(1):3-7.

PMID: 15872394

To predict healing of the stump by assessing the microscopic vascular changes at the amputation site.

Armigeres subalbatus incriminated as an important vector of the dog heartworm Dirofilaria immitis and the bird Cardiofilaria in urban Kuala Lumpur

Cheong WH, Mak JW, Naidu S, Mahadevan S

Southeast Asian J Trop Med Public Health, 1981 Dec;12(4):611-2.

PMID: 6124044

The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children

Kamath NP, Tandon S, Nayak R, Naidu S, Anand PS, Kamath YS

Eur Arch Paediatr Dent, 2020 Feb;21(1):61-66.

PMID: 31111439 DOI: 10.1007/s40368-019-00445-5

PURPOSE: To evaluate the effect of two herbal mouthwashes containing aloe vera and tea tree oil, on the oral health of school children.

METHODS: A double-blinded, placebo-controlled prospective interventional study was conducted in school children aged 8-14 years. The study participants were divided into four groups depending upon the mouthwash used: Group 1 (aloe vera), Group 2 (chlorhexidine), Group 3 (tea tree oil) and Group 4 (placebo). The variables studied included plaque index, gingival index and salivary Streptococcus mutans counts, which were recorded at baseline, 4 weeks after supervised mouth rinse and after 2 weeks of stopping the mouth rinse.

RESULTS: A total of 89 boys and 63 girls were included. A statistically significant decrease in all variables was noted after the use of both the herbal preparations at the end of 4 weeks which was maintained after the 2-week washout period (p S. mutans in the oral cavity in children. The activity of these two agents is comparable to that of chlorhexidine.

Fulltext Efficacy of Concomitant Therapy with Fluoride and Chlorhexidine Varnish on Remineralization of Incipient Lesions in Young Children

Naidu S, Tandon S, Nayak R, Ratnanag PV, Prajapati D, Kamath N

Int J Clin Pediatr Dent, 2016 Oct-Dec;9(4):296-302.

PMID: 28127159 DOI: 10.5005/jp-journals-10005-1381

To assess the effect of combined use of chlorhexidine and fluoride varnish on the remineralization of incipient carious lesions in young children.

Fulltext Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.

Autophagy, 2021 Jan;17(1):1-382.

PMID: 33634751 DOI: 10.1080/15548627.2020.1797280

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

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