The aim of this work was to investigate the effect of glycerol concentration on mechanical
and physical properties of gellan gum (GG) biofilm. The biofilm was prepared using solvent
casting method and the effective glycerol concentration was found to be within 30-50%
w/w (based on GG weight). At 60 and 70 w/w% of glycerol, the films started to distort
because the films was flexible and brittle. As glycerol concentration was increased the tensile
strength (TS) and Youngs modulus (E) of films decreased. Somehow, elongation at break
(EAB), water vapor transmission rate (WVTR) and swelling of films was increased. Glycerol
plasticized GG biofilm was thermally stable and flexible, proposed its can be exploited as
film-forming material and with optimized glycerol concentration it has good mechanical and
physical properties for edible biofilm.
This study examined the effect of honey in gellan gum (GG) hydrogel containing virgin
coconut oil (VCO). Their mechanical, physical, thermal properties and in-vivo healing potential
on dermal wounds were investigated. The compression performance results show that
the inclusion of honey into gellan gum incorporated VCO (GGVCOH) hydrogel improved
the compressive stress of the materials by 3-fold and workable to be applied on the different
contours of human body. Swelling ratio of GVCO hydrogels increased upon addition of
honey, and water transmission rates (WVTRs) values of all hydrogels were in the range of
112-132 g m−2 d
−1
, in which comparable to WVTRs values of commercial wound dressings.
Thermal behavior shows the inclusion of honey in GVCO hydrogels improved the thermal
stability particularly at high concentration. In-vivo healing on dermal wounds exhibits that
the inclusion of honey accelerated the wound closure and shows complete neo-epidermal
of the wounds. The GVCOH hydrogel has shown promising results to treats acute wound
treatments.
Herein, we report the synthesis of a thiosemicarbazide derivatives, namely 4-(2-
fluorophenyl) thiosemicarbazide from the reaction between 2-fluorophenyl isothiocyanate and
hydrazine hydrate. The isolated solid compound was elucidated from micro-elemental analysis
and IR spectroscopy. The structure of the molecule in the ground state was calculated
using density functional theory (DFT) method and basic set of 6-311G (d,p) was used to
calculate the energy gap (4Egap), hardness (η), softness (σ) and the global electronegativity
(χ). Its electrostatic potential mapping and frontier orbital energy analysis were also
discussed. The interaction of the molecule with selected proteins are investigated using
SwissTargetPrediction database.