Superficial angiomyxoma (SA) is an angiomyxoid cutaneous tumour. It has predilection for the head and neck, torso, limbs and genital tract. Our case is a 27-year-old female, presented with painless right medial canthal mass for two years. It was associated with tearing when the lesion grew larger. We received a nodular brownish tissue measuring 25x20x15mm with homogenous brownish cut surface. Microscopically, the tumour was partially circumscribed, exhibiting bland stellate to spindle cells of moderate cellularity with pale eosinophilic cytoplasm, indistinct border, in a loose collagenous myxoid matrix with numerous blood vessels of different calibre. The lesional cells were present at the resected margin and were nonreactive towards CD34, SMA and S100. SA of the eyelid is sometimes mistaken clinically as dermoid cyst or lipoma. Reports have shown increased risks of local recurrence following incomplete excision. Close association with Carney’s complex is an important feature. Careful clinicopathologic correlation and proper investigations are needed for optimal patient care.
Introduction: Breast cancer is ranked first among other cancers in women. Ineffectiveness of current treatments and adverse effects such as multiple organ failure and nephrotoxicity are the common problems faced in cancer therapy. Therefore, alternatives to treat breast cancer metastasis with fewer toxic effects are actively sought-after. Dillenia suffruticosa (DS) commonly known as ‘Simpoh air’ has been a traditional remedy for cancer growth. Therefore, this study investigated the metastasis inhibiting properties of DS root dichloromethane extract (DCMDS) in tumour bearing female BALB/c mice and sub-acute multiple dose oral toxicity upon treatment with this extract. Methods: Forty-eight tumour bearing mice were given either oral treatment of DCMDS (50, 100 and 200 mg/kg) or doxorubicin (2 mg/kg) for 28 days and the degree of metastasis was analysed in each group. Thirty other female BALB/c mice were treated with DCMDS (50, 100 and 200 mg/kg) and the general behaviours, biochemical, haematological and histo- pathological changes were observed. Data were analysed with One-way ANOVA and Dunnet’s test where p
Ulcers in the gastrointestinal tract refer to any appreciable depth of break in the mucosa lining that may involve submucosa. Common types of ulcer include peptic, gastric and duodenal ulcer, which may lead to chronic inflammation. Ulcers may be caused by excessive alcohol intake or prolonged use of non-steroidal anti-inflammatory drugs (NSAID), in addition to several other factors. Conventional medication such as Omeprazole (proton pump inhibitor) and Ranitidine (H2 blockers) for management of ulcers may cause severe side effects such as myelosupression and abnormal heart rhythm. This has driven researchers to explore the potential of natural products for management of ulcers with reduced side effects. Kelulut honey (KH) is a type of honey that is produced by stingless bees from the Trigona species. It is believed to have a lot of medicinal properties such as being antimicrobial, antioxidant and antidiabetic. Yet, no scientific study has been carried out on its antiulcer properties. This study was carried out to determine the antiulcer properties of KH. Eighteen male Sprague dawley rats (5 to 6 weeks old, weighing between 200 and 300 g) were divided into three groups (n=6). The groups were 1) normal control group (without ulcer, without KH), 2) positive control group (with ulcer, without KH) and 3) treatment group (with ulcer, treated with KH). The treatment, KH (1183 mg/kg), was given twice daily for 30 consecutive days by oral administration. On Day 31, the rats were induced with absolute ethanol (5 mL/kg) via oral administration after being fasted for 24 h and were sacrificed 15 min after the induction. The stomach was collected for macroscopic and histopathological evaluation. Pretreatment with KH significantly reduced (p