This study conducted on the structure of modified acrylamide-based hydrogel by synthesizing the nano composites. The hydrogels employed in this study were provided through a combination of acrylamide monomers, sodium carboxymethyl cellulose (NaCMC) and magnesium oxide (MgO) nanoparticles by crosslinking polymerization. N,N,N',N'-tetramethylethylenediamine and ammonium persulfate as the initiator was applied in the structure of the polymer. Findings of the study considered the nano composites consisting of MgO have the highest swelling ratio compared to pure Aam hydrogels. Thus, MgO is an appropriate nanoparticle to be used in the nano composites. Response surface methodology (RSM) based on a central composite design (CCD Design) was applied to optimize the preparation variables of a hydrogel consisted of MgO, NaCMC. With the swelling ratio for acrylamide-based hydrogel as the response, the effects of two variables, i.e. MgO and NaCMC were investigated. The effects of pH, temperature, MgO, and NaCMC on the drug release were investigated using the CCD design. The predicted appropriate drug release conditions for the hydrogel at the highest rate of temperature (37.50 °C) and pH: 4.10, is at its highest value, while the lower drug release is at temperature 38 °C and pH 3.50. With the desired value of MgO (0.01 g) and amount of NaCMC (0.1 g).
The design of carriers for insulin delivery has recently attracted major research attentions in the biomedical field. In general, the release of drug from polymers is driven via a variety of polymers. Several mechanisms such as matrix release, leaching of drug, swelling, and diffusion are usually adopted for the release of drug through polymers. Insulin is one of the most predominant therapeutic drugs for the treatment of both diabetes mellitus; type-I (insulin-dependent) and type II (insulin-independent). Currently, insulin is administered subcutaneously, which makes the patient feel discomfort, pain, hyperinsulinemia, allergic responses, lipodystrophy surrounding the injection area, and occurrence of miscarried glycemic control. Therefore, significant research interest has been focused on designing and developing new insulin delivery technologies to control blood glucose levels and time, which can enhance the patient compliance simultaneously through alternative routes as non-invasive insulin delivery. The aim of this review is to emphasize various non-invasive insulin delivery mechanisms including oral, transdermal, rectal, vaginal, ocular, and nasal. In addition, this review highlights different smart stimuli-responsive insulin delivery systems including glucose, pH, enzymes, near-infrared, ultrasound, magnetic and electric fields, and the application of various polymers as insulin carriers. Finally, the advantages, limitations, and the effect of each non-invasive route on insulin delivery are discussed in detail.
The development of eco-friendly and efficient technologies for treating wastewater is one of the attractive research area. Phytoremediation is considered to be a possible method for the removal of pollutants present in wastewater and recognized as a better green remediation technology. Nowadays the focus is to look for a sustainable approach in developing wastewater treatment capability. Water hyacinth is one of the ancient technology that has been still used in the modern era. Although, many papers in relation to wastewater treatment using water hyacinth have been published, recently removal of organic, inorganic and heavy metal have not been reviewed extensively. The main objective of this paper is to review the possibility of using water hyacinth for the removal of pollutants present in different types of wastewater. Water hyacinth is although reported to be as one of the most problematic plants worldwide due to its uncontrollable growth in water bodies but its quest for nutrient absorption has provided way for its usage in phytoremediation, along with the combination of herbicidal control, integratated biological control and watershed management controlling nutrient supply to control its growth. Moreover as a part of solving wastewater treatment problems in urban or industrial areas using this plant, a large number of useful byproducts can be developed like animal and fish feed, power plant energy (briquette), ethanol, biogas, composting and fiber board making. In focus to the future aspects of phytoremediation, the utilization of invasive plants in pollution abatement phytotechnologies can certainly assist for their sustainable management in treating waste water.