Xenobiotic substance released in the environment is a concern among the public at large. The example of this xenobiotic release into the environment is xenoestrogens. Xenoestrogens have the capability to bind to the estrogen receptors in the body even at low affinity. Food, pesticides and contraceptive pills are known sources of xenoestrogens. In this study, acute toxicity test was conducted to evaluate toxicity of synthetic estrogen such as estradiol to the embryo-larvae of zebrafish model. Morphological changes in the embryo-larvae of zebrafish were also observed. The parameters that were evaluated in acute toxicity study were half lethal concentration (LC50) and few apical endpoints such as coagulation of embryos, development of pericardial edema, and eyes size. Toxicity effect of the compound was evaluated in term of behavior activity of the larvae. Results showed that certain concentration of estradiol caused toxic effects to the embryo-larvae of the zebrafish (p
Reproductive and Maternal health are an important components of public health and medicine which are concerned with the complete state of physical, mental and social wellbeing in all matters regarding reproductive system and health of mother especially during pregnancy.It implies ensuring that all women receive the care they need to be safe and healthy throughout pregnancy, childbirth and beyond. However, according to World Health Organization, millions of women all over the world do not have access to good quality health services during pregnancy and childbirth resulting in mortalities. Islam is a complete way of life. The Qur’an and Hadith consider pregnancy and child bearing as signs among other signs of the divine existence of Allah.The importance of maternal and reproductive is thus not unexplained in the Islamic perspectives. The study look at what role Muslim religious leaders can play in the prevention of maternal deaths and morbidities in developing countries. A qualitative study was conducted through in-depth interviews and focus groups discussion with a purposive sample of some Muslim religious leaders from Gusau local government area of Zamfara state northwest Nigeria in order to elicit information about the Islamic perspectives of reproductive and maternal health and the roles they can play in the prevention of maternal deaths among the Muslim communities. Muslim Religious leaders have a crucial role and contribution for the attainment and maintenance of good heath of women and children among Muslim communities through public enlightenment in the context of ‘ilm’, providing guidance through ‘Fatwah’ and community mobilization in the spirit brotherhood ‘ukhuwah’.Islam does not accept the “preventable death of a woman” due to childbirth or pregnancy. Thus, Islam encourages attendance of antenatal care visits and health care seeking.
Objectives/Research Problem:Melastoma malabathricum L., (Melastomaceae) is a medicinally important plant known as “Senduduk”. Traditionally, the leaves are used to relieve diverse pain-related ailments. Present study aims to examine the antinociceptive activity of methanolic extract of M. malabathricum (MEMM) leaves and its fractions via in vivo models of nociception.
Materials and Method: Extracts (100, 250, 500 mg/kg) were administered orally 60 minutes prior to subjection to the respective test, n=6/group. Evaluation of MEMM antinociceptive activity; chemically (acetic acid-induced abdominal constriction; ACT, formalin-induced paw licking test; FT) and thermally (hot plate test; HT) models of nociception and elucidation of mechanisms of action involved; role of opioid, vanilloid receptors, glutamatergic system and NO/cGMP pathway were determined. Continuously, MEMM, partitioned into three fractions: petroleum ether (PEMM), ethyl acetate (EAMM), and aqueous (AQMM) extracts and determine the most potent fraction. Therefore, experiment ED50 and its 95% confidence intervals (CI) values were conducted, and ACT was used to screen. Calculation, obtained, PEMM, the most effective was further used to assess the antinociceptive properties. Phytochemical screening, HPLC and GC-MS analysis were performed.
Results and Discussion: First stage, MEMM exhibited significant (P
Exposure to cyclophosphamide (CPA) for cancer treatment results in over-production of reactive oxygen species and oxidative stress thus affecting the DNA in male germ cell inducing sperm defects. Our goal is to assess the potential effects of Nigella sativa extract (NSE) and thymoquinone (TQ) on sperm and embryo quality following fertlization of sperm produced from germ cells which have been exposed to the damaging alkylating effects of CPA.