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Preliminary data on the validity and reliability of the Malay version of the NUCOG

Chandrasekaran PK, Walterfang MA, Velakoulis D

Asian J Psychiatr, 2010 Dec;3(4):186-9.

PMID: 23050885 DOI: 10.1016/j.ajp.2010.10.001

The Neuropsychiatry Unit Cognitive Screening Instrument (NUCOG) provides more detailed screening of cognition than most commonly available tools and was selected for translation into and validation in Bahasa Malaysia (Malay language). It was first translated to Malay, then back-translated to English until changes made were comparable to the original English version. The Malay-translated NUCOG and the Malay version of the Mini-Mental State Examination (MMSE) were delivered to Malay-speaking subjects (n=24). The Malay NUCOG version was then validated by correlating scores against the Malay version of the MMSE and the data tested for reliability of the tool. The Malay version of the NUCOG proved to be a valid (r=0.98, p<0.001) and internally consistent (Cronbach's α=0.76) tool to assess cognitive function and this multi-dimensional cognitive screening instrument is likely to be valuable in the cognitive assessment of neuropsychiatric patients in Malay.

Skin Picking Heralding Parkinson's Disease

Chee KY, Evans AH, Velakoulis D

J Neuropsychiatry Clin Neurosci, 2016;28(2):e23-4.

PMID: 27093384 DOI: 10.1176/appi.neuropsych.15100250

Psychometric properties of Malay neuropsychiatry unit cognitive assessment tool among Alzheimer's disease patients in comparison to Malay Montreal Cognitive Assessment

Thong KS, Chee KY, Ng CG, Walterfang M, Velakoulis D

Asia Pac Psychiatry, 2016 Sep;8(3):238-40.

PMID: 26615809 DOI: 10.1111/appy.12227

This study aims to establish psychometric properties of the Malay Neuropsychiatry Unit Cognitive Assessment Tool (Malay NuCOG) in Alzheimer's disease. NuCOG was translated to Malay language and compared with Montreal Cognitive Assessment Tool on 80 individuals. The Malay NuCOG showed good internal consistency and reliability (Cronbach's alpha = 0.895). It demonstrated 100% sensitivity and 87.5% specificity at the cutoff score of 78.50/100. The Malay NuCOG is a valid and reliable cognitive instrument that is sensitive and specific for the detection of dementia and has clinical advantages in its ability to examine individual cognitive domains.

A case of TREM2 mutation presenting with features of progressive non-fluent aphasia and without bone involvement

Chee KY, Gaillard F, Velakoulis D, Ang CL, Chin LK, Ariffin R

Aust N Z J Psychiatry, 2017 Nov;51(11):1157-1158.

PMID: 28462591 DOI: 10.1177/0004867417707821

A case of early-onset familial Alzheimer's disease with both APP and novel PSEN2 mutations presenting with non-amnestic features

Chee KY, Yee OK, Gaillard F, Velakoulis D, Mohd Zain NR, Yogendren L, et al.

Aust N Z J Psychiatry, 2017 Dec;51(12):1252-1253.

PMID: 28762277 DOI: 10.1177/0004867417722642

Fulltext Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting

Eratne D, Kang MJY, Lewis C, Dang C, Malpas CB, Keem M, et al.

Alzheimers Dement, 2024 Nov;20(11):7989-8001.

PMID: 39369278 DOI: 10.1002/alz.14278

INTRODUCTION: People with neurodegenerative disorders (ND) frequently face diagnostic delay and misdiagnosis. We investigated blood and cerebrospinal fluid (CSF) neurofilament light chain (NfL) to distinguish ND from primary psychiatric disorders (PPD), a common challenge in clinical settings.

METHODS: Plasma and CSF NfL levels were measured and compared between groups, adjusting for age, sex, and weight.

RESULTS: A total of 337 participants were included: 136 ND, 77 PPD, and 124 Controls. Plasma NfL was 2.5-fold elevated in ND compared to PPD and had strong diagnostic performance (area under the curve, [AUC]: 0.86, 81%/85% specificity/sensitivity) that was comparable to CSF NfL (2-fold elevated, AUC: 0.89, 95%/71% specificity/sensitivity). Diagnostic performance was especially strong in younger people (40-

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