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NMR characterization of guanine DNA site alkylated by kapurimycin A3, an antitumour antibiotic from Streptomyces sp
Chan KL, Sugiyama H, Saito I, Hara M
Phytochemistry
, 1995 Nov;40(5):1373-4.
PMID: 8534399
Abstract
The kapurimycin A3-guanine adduct was formed by alkylation of the antitumour antibiotic with d(CGCG)2. The site of alkylation of the guanine was confirmed by comparative NMR studies with N-7-methyl-guanine in DMSO-d6.
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Anthracenes/pharmacology
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