NMR characterization of guanine DNA site alkylated by kapurimycin A3, an antitumour antibiotic from Streptomyces sp

Chan KL 1 , Sugiyama H , Saito I , Hara M

Affiliations 

  • 1 School of Pharmnaceutical Sciences, University of Science Malaysia, Penang, Malaysia
Phytochemistry, 1995 Nov;40(5):1373-4.
PMID: 8534399

Abstract

The kapurimycin A3-guanine adduct was formed by alkylation of the antitumour antibiotic with d(CGCG)2. The site of alkylation of the guanine was confirmed by comparative NMR studies with N-7-methyl-guanine in DMSO-d6.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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