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Metronidazole leads to enhanced uptake of imatinib in brain, liver and kidney without affecting its plasma pharmacokinetics in mice
Tan SY, Kan E, Lim WY, Chay G, Law JH, Soo GW, et al.
J Pharm Pharmacol
, 2011 Jul;63(7):918-25.
PMID: 21635257
DOI:
10.1111/j.2042-7158.2011.01296.x
Abstract
The pharmacokinetic interaction between metronidazole, an antibiotic-antiparasitic drug used to treat anaerobic bacterial and protozoal infections, and imatinib, a CYP3A4, P-glycoprotein substrate kinase inhibitor anticancer drug, was evaluated.
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Antiprotozoal Agents/adverse effects
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