Metronidazole leads to enhanced uptake of imatinib in brain, liver and kidney without affecting its plasma pharmacokinetics in mice

Tan SY 1 , Kan E , Lim WY , Chay G , Law JH , Soo GW Show all authors , Bukhari NI , Segarra I

Affiliations 

  • 1 Department of Pharmaceutical Technology, School of Pharmacy and Health Sciences, International Medical University, Kuala Lumpur, Malaysia
J Pharm Pharmacol, 2011 Jul;63(7):918-25.
PMID: 21635257 DOI: 10.1111/j.2042-7158.2011.01296.x

Abstract

The pharmacokinetic interaction between metronidazole, an antibiotic-antiparasitic drug used to treat anaerobic bacterial and protozoal infections, and imatinib, a CYP3A4, P-glycoprotein substrate kinase inhibitor anticancer drug, was evaluated.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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