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Fulltext Percutaneous transluminal coronary angioplasty in the treatment of coronary artery disease--the local experience: a review of 100 cases

Ng SC, Hitam O, Sawat

Med J Malaysia, 1991 Mar;46(1):59-65.

PMID: 1836039

This paper reviews our first 100 consecutive PTCAs done between December 1988 and May 1990. There were 31 females and 69 males and their ages ranged from 37 years to 80 years. The mean age was 57.7 years. We achieved a follow-up rate of 66%. The restenosis rate was 22% of those that we could follow-up. There were 35 simple and 65 complex PTCAs. An average of 1.39 arteries were entered per PTCA. Of the 100 PTCAs done there was a primary success rate of 83%. On closer examination most of the failures were in the total occlusion group. There were 30 total occlusions done and 17 were successfully dilated. The primary success rate for acute total occlusions was 77% and the primary success rate for chronic total occlusions was 41%. Of the 100 PTCAs there were two deaths and only one patient had to go for emergency bypass surgery. The other complications were relatively minor including hypotension, groin bleeding, chills and rigors. This paper documents our initial 100 cases of PTCAs. It shows that our figures are compatible with other centres in this region and those around the world.

Matched MeSH terms: Coronary Disease/therapy*

Computed tomography scan for cardiac interventions

Sim KH, Ong TK, Chin SP, Wong M

Indian Heart J, 2007 Mar-Apr;59(2 Suppl B):B25-32.

PMID: 19153433

Matched MeSH terms: Coronary Disease/therapy*

Fulltext Coronary stents in the management of coronary artery disease review of first 100 stents

Ng SC, Sawatt C, Foo LK, Hitam O, Khor PG, Lee YK

Med J Malaysia, 1996 Mar;51(1):75-9.

PMID: 10967983

This is a review of the first 100 coronary stents implanted for the indications of PTCA restenosis, acute or threatened closure and De Novo lesions. The success rates were high and complications rates were low. Subacute stent thrombosis rates were low and stenting for De Novo lesions in > 3.0 mm arteries provide the best short and long term results. Six months restenosis rate was low. Stent assisted high pressure balloon angioplasty is an important advance.

Matched MeSH terms: Coronary Disease/therapy*

Therapeutic angiogenesis for severe ischemic heart diseases by autologous bone marrow cells transplantation

Hattori R, Matsubara H

Mol Cell Biochem, 2004 Sep;264(1-2):151-5.

PMID: 15544044

Conventional therapies for severe ischemic heart disease are limited in applicability. While several angiogenesis researches have shown novel efficacy, safety and feasibility for clinical use, recently we have started the clinical trial of a sole cell therapy using autologous bone marrow mononuclear cells transplantation targeted into ischemic hibernating myocardium. Here, we review the background of bone marrow cell research and introduce therapeutic angiogenesis for severe ischemic heart disease by autologous bone marrow cells transplantation.

Matched MeSH terms: Coronary Disease/therapy*

Fulltext Percutaneous coronary intervention in Asians--are there differences in clinical outcome?

Koh AS, Khin LW, Choi LM, Sim LL, Chua TS, Koh TH, et al.

BMC Cardiovasc Disord, 2011;11:22.

PMID: 21605387 DOI: 10.1186/1471-2261-11-22

Ethnic differences in clinical outcome after percutaneous coronary intervention (PCI) have been reported. Data within different Asian subpopulations is scarce. We aim to explore the differences in clinical profile and outcome between Chinese, Malay and Indian Asian patients who undergo PCI for coronary artery disease (CAD).

Matched MeSH terms: Coronary Disease/therapy*

Fulltext Cholesterol goal achievement and lipid-lowering therapy in patients with stable or acute coronary heart disease in Singapore: results from the Dyslipidemia International Study II

Poh KK, Chin CT, Tong KL, Tan JKB, Lim JS, Yu W, et al.

Singapore Med J, 2019 Sep;60(9):454-462.

PMID: 30773600 DOI: 10.11622/smedj.2019021

INTRODUCTION: Dyslipidaemia is a major risk factor for coronary heart disease (CHD). There is a lack of data on the extent of lipid abnormalities and lipid-lowering therapy (LLT) in Singapore.

METHODS: The Dyslipidemia International Study (DYSIS) II was a multinational observational study of patients with stable CHD and hospitalised patients with an acute coronary syndrome (ACS). A full lipid profile and use of LLT were documented at baseline, and for the ACS cohort, at four months post-hospitalisation.

RESULTS: 325 patients were recruited from four sites in Singapore; 199 had stable CHD and 126 were hospitalised with an ACS. At baseline, 96.5% of the CHD cohort and 66.4% of the ACS cohort were being treated with LLT. In both cohorts, low-density lipoprotein cholesterol (LDL-C) levels were lower for the treated than the non-treated patients; accordingly, a higher proportion of patients met the LDL-C goal of < 70 mg/dL (CHD: 28.1% vs. 0%, p = 0.10; ACS: 20.2% vs. 0%, p < 0.01). By the four-month follow-up, a higher proportion of the ACS patients that were originally not treated with LLT had met the LDL-C goal (from 0% to 54.5%), correlating with the increased use of medication. However, there was negligible improvement in the patients who were treated prior to the ACS.

CONCLUSION: Dyslipidaemia is a significant concern in Singapore, with few patients with stable or acute CHD meeting the recommended European Society of Cardiology/European Atherosclerosis Society goal. LLT was widely used but not optimised, indicating considerable scope for improved management of these very-high-risk patients.

Matched MeSH terms: Coronary Disease/therapy*

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