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Acquired platelet dysfunction with eosinophilia in white children

Poon MC, Ng SC, Coppes MJ

J Pediatr, 1995 Jun;126(6):959-61.

Acquired platelet dysfunction associated with eosinophilia has been described mainly in indigenous Southeast Asian and East Indian children. We describe two white boys in whom this disorder developed after they had lived in Malaysia for 12 to 18 months. Acquired platelet dysfunction associated with eosinophilia should therefore be considered in children who, after a visit to this region, have easy bruising and esoinophilia.

Matched MeSH terms: Eosinophilia/epidemiology

Two cases of tropical pulmonary eosinophilia from Sabah

Barclay R

Med J Malaya, 1966 Dec;21(2):131-2.

PMID: 4227383

Matched MeSH terms: Eosinophilia/epidemiology*

Intestinal parasites, eosinophilia, haemoglobin and gamma globulin of Malay, Chinese and Indian schoolchildren

Bisseru B, Abdul Aziz bin Ahmad

Med J Malaya, 1970 Sep;25(1):29-33.

PMID: 4098546

Matched MeSH terms: Eosinophilia/epidemiology*

Fulltext Distribution of anti-Toxoplasma gondii antibodies among Orang Asli (aborigines) in Peninsular Malaysia

Hakim SL, Radzan T, Nazma M

Southeast Asian J. Trop. Med. Public Health, 1994 Sep;25(3):485-9.

PMID: 7777912

The distribution of anti-toxoplasma antibodies among the aborigines in Malaysia and its association with other soil transmitted infections and eosinophilia were studied. A total of 415 serum samples were collected and tested by IFA test. Overall prevalence was 10.6%, lower than previously reported. The antibody titers showed a unimodal distribution peaking at 1:8 dilution. There was a higher proportion of high antibody titer (> 1:128) in the adult compared to the children with no significant difference in prevalence rate by sex. The pattern of infection does not differ from other soil transmitted infections and there was no association between raised Toxoplasma antibodies with eosinophilia.

Matched MeSH terms: Eosinophilia/epidemiology

An outbreak of acute eosinophilic myositis attributed to human Sarcocystis parasitism

Arness MK, Brown JD, Dubey JP, Neafie RC, Granstrom DE

Am J Trop Med Hyg, 1999 Oct;61(4):548-53.

PMID: 10548287

Seven members of a 15-man U.S. military team that had operated in rural Malaysia developed an acute illness consisting of fever, myalgias, bronchospasm, fleeting pruritic rashes, transient lymphadenopathy, and subcutaneous nodules associated with eosinophilia, elevated erythrocyte sedimentation rate, and elevated levels of muscle creatinine kinase. Sarcocysts of an unidentified Sarcocystis species were found in skeletal muscle biopsies of the index case. Albendazole ameliorated symptoms in the index case; however, his symptoms persisted for more than 5 years. Symptoms in 5 other men were mild to moderate and self-limited, and 1 team member with laboratory abnormalities was asymptomatic. Of 8 team members tested for antibody to Sarcocystis, 6 were positive; of 4 with the eosinophilic myositis syndrome who were tested, all were positive. We attribute this outbreak of eosinophilic myositis to accidental tissue parasitism by Sarcocystis.

Matched MeSH terms: Eosinophilia/epidemiology

Fulltext A Prospective Study on the Prevalence, Extent of Disease and Outcome of Eosinophilic Gastroenteritis in Patients Presenting with Lower Abdominal Symptoms

Hui CK, Hui NK

Gut Liver, 2018 May 15;12(3):288-296.

PMID: 29212311 DOI: 10.5009/gnl17056

Background/Aims: The epidemiology of eosinophilic gastroenteritis remains unclear. We aim to determine the prevalence of eosinophilic gastroenteritis in patients with lower abdominal symptoms.

Methods: In a prospective study, colonoscopy was performed on 2,469 consecutive patients. Biopsies were taken from the terminal ileum and ascending, transverse, descending and sigmoid colon in all patients.

Results: Sixty-four of the 2,469 patients (2.6%) had eosinophilic gastroenteritis. Only five of the 64 patients (7.8%) with eosinophilic gastroenteritis had endoscopic mucosal abnormalities during colonoscopy. Six of these 64 patients (9.4%) had severe disease at presentation, and seven of these 64 patients (10.9%) required systemic steroid treatment. An elevated absolute peripheral eosinophil count was independently associated with severe disease at presentation (4/6 [66.7%] vs 3/58 [5.2%], p=0.005; odds ratio [OR], 25.320; 95% confidence interval [CI], 2.628 to 243.910), and severe disease at the time of presentation was independently associated with the use of systemic steroid treatment (6/7 [85.7%] vs 0/57 [0%], p=0.008; OR, 18.021; 95% CI, 2.163 to 150.152).

Conclusions: The prevalence of eosinophilic gastroenteritis is common, and patients usually present normal-appearing mucosa on colonoscopy. Those with severe disease at presentation usually have a raised absolute peripheral eosinophil count and should be commenced on systemic steroids as an initial therapy.

Matched MeSH terms: Eosinophilia/epidemiology

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