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  1. Fulltext Effects of high-intensity functional training on physical fitness in healthy individuals: a systematic review with meta-analysis
    Wang X, Soh KG, Zhang L, Liu X, Ma S, Zhao Y, et al.
    BMC Public Health, 2025 Feb 10;25(1):528.
    PMID: 39930392 DOI: 10.1186/s12889-025-21538-5
    The purpose of this study was to conduct a meta-analysis of the effects of high-intensity functional training on the physical fitness of healthy individuals. This system review followed the PRISMA guidelines and has been registered in PROSPERO with the registration number CRD42023475055. As of January 2024, we did a thorough search across five databases: PubMed, Scopus, Web of Science, EBSCOhost, and Cochrane Library. We evaluated the methodological quality of the included study by TEST EX tool and ROB 2 tool. GRADE framework determines the level of certainty of evidence. Meta-analysis of random effects model calculations. 19 high-quality studies were included in this review, involving 911 healthy individuals. Positive effects were observed in improving strength (ES = 1.380; p high-quality research to explore the impact of HIFT on the physical fitness in healthy individuals.
    Matched MeSH terms: High-Intensity Interval Training/methods
  2. High-intensity interval training induced PGC-1∝ and AdipoR1 gene expressions and improved insulin sensitivity in obese individuals
    Asilah Za'don NH, Amirul Farhana MK, Farhanim I, Sharifah Izwan TO, Appukutty M, Salim N, et al.
    Med J Malaysia, 2019 12;74(6):461-467.
    PMID: 31929469
    INTRODUCTION: High-intensity interval training (HIIT) has been found to improve cardiometabolic health outcome as compared to moderate-intensity continuous exercise. However, there is still limited data on the benefits of HIIT on the expression of regulatory proteins that are linked to skeletal muscle metabolism and insulin sensitivity in obese adults. This study investigated the effects of HIIT intervention on expressions of peroxisome proliferatoractivated receptor-γ coactivator 1-∝ (PGC-1∝) and adiponectin receptor-1 (AdipoR1), insulin sensitivity (HOMAIR index), and body composition in overweight/obese individuals.

    METHODS: Fifty overweight/obese individuals aged 22-29 years were assigned to either no-exercise control (n=25) or HIIT (n=25) group. The HIIT group underwent a 12-week intervention, three days/week, with intensity of 65-80% of age-based maximum heart rate. Anthropometric measurements, homeostatic model of insulin resistance (HOMA-IR) and gene expression analysis were conducted at baseline and post intervention.

    RESULTS: Significant time-by-group interactions (p<0.001) were found for body weight, BMI, waist circumference and body fat percentage. The HIIT group had lower body weight (2.3%, p<0.001), BMI (2.7%, p<0.001), waist circumference (2.4%, p<0.001) and body fat percentage (4.3%, p<0.001) post intervention. Compared to baseline, expressions of PGC-1∝ and AdipoR1 were increased by approximately three-fold (p=0.019) and two-fold (p=0.003) respectively, along with improved insulin sensitivity (33%, p=0.019) in the HIIT group.

    CONCLUSION: Findings suggest that HIIT possibly improved insulin sensitivity through modulation of PGC-1∝ and AdipoR1. This study also showed that improved metabolic responses can occur despite modest reduction in body weight in overweight/obese individuals undergoing HIIT intervention.

    Matched MeSH terms: High-Intensity Interval Training/methods*
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