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  1. Falsely low serum creatinine caused by immunoglobulin M paraprotein interference with enzymatic method
    Ting HY, Ting IPL, Lo SC, Loh TP
    Pathology, 2022 Dec;54(7):959-962.
    PMID: 35527046 DOI: 10.1016/j.pathol.2022.01.012
    Matched MeSH terms: Paraproteins*
  2. Survey on serum protein electrophoresis and recommendations for standardised reporting
    Sthaneshwar P, Thambiah SC, Mat Salleh MJ, Nasuruddin DN, Ahmad Zabidi NF, Jelani AM, et al.
    Malays J Pathol, 2021 Aug;43(2):281-290.
    PMID: 34448792
    INTRODUCTION: Serum protein electrophoresis (SPE) is a well-established laboratory technique. However, reporting of results varies considerably between laboratories. The variation in reporting can cause confusion to the clinician with a potential of adversely impacting patient care. The purpose of the survey was to find out the variation in reporting and to prepare recommendations to the Malaysian laboratories based on the survey to reduce both the variation in reporting between laboratories and the risk of misinterpretation of reports.

    MATERIALS AND METHODS: To determine the extent of variation in reporting of protein electrophoresis results questionnaires were distributed to the pathologists of various laboratories in Malaysia regarding the method, quantification of paraprotein concentrations and immunoglobulin assays, and information regarding current laboratory electrophoresis practices.

    RESULTS: Variation was found in the following reporting practices: (a) screening protocol; (b) reporting of serum albumin; (c) numerical reporting of protein fractions and paraprotein; (d) co-migration of a paraprotein with a normal serum protein; (e) reporting of multiple paraprotein bands (f) appearance of small abnormal band and oligoclonal bands and (g) communication about of interferences.

    CONCLUSION: The pathologists of the country made recommendations on the reporting of protein electrophoresis. Harmonised reporting will reduce inconsistency, variation in reporting, improve the quality of the report and most importantly improve patient care.

    Matched MeSH terms: Paraproteins
  3. Fulltext Monoclonal gammopathy with systemic amyloidosis: an evaluation of diagnostic elements
    Subashini, C. T., George, E., Nor Aini, U.
    Malaysian Journal of Medicine and Health Sciences, 2011;7(1):51-55.
    MyJurnal
    Monoclonal gammopathies result from an overproduction of a single abnormal clone of plasma cell
    or B lymphocyte that produce an immunologically homogenous immunoglobulin (Ig) commonly referred to as paraprotein or monoclonal (M) protein. The circulating M-protein may consist of an intact immunoglobulin, the light chain only, or (rarely) the heavy chain only. The heavy chain is from one of the five immunoglobulin classes G, A, M, D or E, while the light chain is either kappa (κ) or lambda (λ) in type. Accurate detection and quantitation of monoclonal immunoglobulins is important for the diagnosis and management of monoclonal gammopathies. We report a case of a 71 year old lady with a history of chronic gastritis and recurrent lower respiratory tract infection whereby no specific diagnosis was made until a computed tomography (CT) guided lung biopsy and orogastroduodenoscopy (OGDS) 5 years later from the onset of initial symptoms revealed pulmonary and gastric amyloidosis, respectively.
    Matched MeSH terms: Paraproteins
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