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  1. Fulltext Preliminary experience with moclobemide for the treatment of depressive disorders in Malaysia
    Indran SK
    Singapore Med J, 1995 Apr;36(2):189-90.
    PMID: 7676265
    The objective of this study was to describe preliminary experience with moclobemide in the treatment of depressive disorders in the University outpatient clinic in Malaysia. Twenty patients who satisfied DSM III R criteria for depressive disorders and scored more than 16 on the Hamilton Rating Depression Score at the initial interview were recruited into this open study. The primary diagnosis of 4 patients was later ascertained to be panic disorder(2), schizophrenia(1) and social phobia(1). Patients rated themselves as improved by first follow up (7-14 days), and rated their depression as very mild to mild by the third follow up visit (ie at a mean of 46 days). Side effects were minimal and compliance good.

    Study site: outpatient psychiatric clinic at the General Hospital, Kuala
    Lumpur.
    Matched MeSH terms: Phobic Disorders/drug therapy
  2. Comparing the efficacy and safety between propofol and dexmedetomidine for sedation in claustrophobic adults undergoing magnetic resonance imaging (PADAM trial)
    Loh PS, Ariffin MA, Rai V, Lai LL, Chan L, Ramli N
    J Clin Anesth, 2016 Nov;34:216-22.
    PMID: 27687378 DOI: 10.1016/j.jclinane.2016.03.074
    STUDY OBJECTIVE: To determine the efficacy of sedation with dexmedetomidine compared to propofol for claustrophobic adults undergoing magnetic resonance imaging (MRI) in our institution.

    DESIGN: Randomized, prospective, double-blinded study.

    SETTING: University-based tertiary referral center.

    PATIENTS: Thirty claustrophobic adults with American Society of Anesthesiologists physical status I and II who were planned for MRI.

    INTERVENTIONS: Patients were randomly assigned to target-controlled infusion propofol or dexmedetomidine loading followed by maintenance dose for procedural sedation.

    MEASUREMENTS AND MAIN RESULTS: The primary end point was adequate reduction in patient anxiety levels to allow successful completion of the MRI sequence. Both methods of sedation adequately reduced anxiety levels in visual analog scale scores and Spielberger Strait Test Anxiety Inventory (P

    Matched MeSH terms: Phobic Disorders/drug therapy*
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