MyMedR

Fulltext N95 respirator associated pressure ulcer amongst COVID-19 health care workers

Lam UN, Md Mydin Siddik NSF, Mohd Yussof SJ, Ibrahim S

Int Wound J, 2020 Oct;17(5):1525-1527.

PMID: 32397010 DOI: 10.1111/iwj.13398

Matched MeSH terms: Pressure Ulcer/etiology*

A study of the psychosomatic aspects of peptic ulcer

Roy RN

Med J Malaya, 1966 Mar;20(3):240-8.

PMID: 4223074

Matched MeSH terms: Peptic Ulcer/etiology*

Fulltext Helicobacter pylori and peptic ulcer disease--a causal link

Goh KL

Med J Malaysia, 1997 Jun;52(2):161-8.

PMID: 10968075

The link between Helicobacter. pylori and peptic ulcer disease in 1997 is an irrefutable one. The association between infection and ulcerogenesis has been shown to be biologically plausible with induction of epithelial inflammation and cell damage and its effect on gastrin/acid homeostasis. The association of H. pylori infection and peptic ulcer disease is a close and consistent one. There is ample evidence indicating that H. pylori eradication results in virtual abolition of ulcer relapse. Several studies have demonstrated that eradication of H. pylori results in ulcer healing and there is evidence showing a temporal relationship between infection and development of peptic ulcer disease.

Matched MeSH terms: Peptic Ulcer/etiology*

Fulltext Free radicals and the pathogenesis of disease

Lim VK

Med J Malaysia, 1993 Dec;48(4):379-80.

PMID: 8183159

Matched MeSH terms: Peptic Ulcer/etiology

Disseminated histoplasmosis presenting as penile ulcer

Jayalakshmi P, Goh KL, Soo-Hoo TS, Daud A

Aust N Z J Med, 1990 Apr;20(2):175-6.

PMID: 2344324

A 59-year-old Chinese man presented with a three month history of penile ulcers and abdominal pain. Syphilis and a gastric malignancy were diagnosed clinically. Biopsy of the genital and stomach ulcers revealed histiocytic granulomata containing numerous intracellular fungal bodies. Histoplasma capsulatum was subsequently cultured from the penile ulcer. Antifungal therapy was instituted. However the patient's general condition deteriorated rapidly and he died within two weeks of admission. A post-mortem liver biopsy showed numerous intracellular fungi.

Matched MeSH terms: Ulcer/etiology

Fulltext Erupted teeth in the newborn

Meon R, Woon KC

Med J Malaysia, 1982 Dec;37(4):306-7.

PMID: 7167080

Incidence, aetiology, morphology, histology and symptoms of natal or neonatal teeth are presented. The commonly used terminology natal and neonatal teeth is adopted in this article. A case of an 8-week old girl with natal tooth and sublingual ulceration of the tip of the tongue is described.

Matched MeSH terms: Ulcer/etiology

Gastric acid secretion in duodenal ulcer disease in the Malaysia-Singapore region

Ti TK

Ann Acad Med Singap, 1983 Oct;12(4):507-17.

PMID: 6678134

Basal and pentagastrin stimulated acid output was measured in 80 normal and 179 duodenal ulcer subjects of Chinese, Indian and Malay origin. Basal and maximally stimulated acid output was significantly higher in duodenal ulcer patients compared with normal subjects. There was however considerable overlap and less than one in four duodenal ulcer patients were hypersecretors. The acid output (and hence the parietal cell mass) was lower than in Caucasian subjects and this was possibly related to weight differences. The acid output did not differ significantly in the Chinese, Indian and Malay subjects, suggesting that parietal cell mass in the three racial groups is closely similar. The difference in frequency of duodenal ulcer disease in the three racial groups is thus not related to gastric secretory capacity.

Matched MeSH terms: Duodenal Ulcer/etiology; Peptic Ulcer/etiology

Oestrogen-soaked vaginal packing for decubitus ulcer in advanced pelvic organ prolapse: a case series

Abdullah B, Khong SY, Tan PC

Int Urogynecol J, 2016 Jul;27(7):1057-62.

PMID: 26718780 DOI: 10.1007/s00192-015-2930-3

INTRODUCTION: Cervicovaginal decubitus ulceration is a well-known complication of advanced pelvic organ prolapse (POP). There is no consensus for its management. This case series describes the outcome of using repeated vaginal packs soaked with oestrogen cream to reduce POP and promote decubitus ulcer healing. We aimed to investigate the speed of ulcer healing and endometrial safety with this regimen.

METHODS: This was a retrospective study of patients with stage 3 or 4 POP and intact uterus with decubitus ulcer who were planned for surgery that included hysterectomy after ulcer healing. Vaginal packs are replaced at least biweekly-or more frequently if extruded-until ulcer resolution.

RESULTS: Thirteen patients were studied. Mean age was 69 ± 6 years and mean duration of menopause was 19 ± 6 years. Nine patients had a single ulcer and four had multiple ulcers. Mean ulcer diameter was 2.8 ± 1.5 cm and mean duration for ulcer healing was 26 ± 14 days. Hysterectomy and pelvic floor reconstruction was performed a median of 5 (range 0-153) days after ulcer healing was first noted. Histopathological examination of the endometrium following hysterectomy showed three specimens with endocervical hyperplasia; one had concurrent proliferative endometrium, two had simple endometrial hyperplasia and another two had proliferative endometrium.

CONCLUSION: Oestrogen-soaked vaginal packing is a viable option for managing a decubitus ulcer in advanced POP. We document a measurable impact on the endometrium with this short-term preoperative regimen. Further research is needed to evaluate its efficacy in promoting ulcer healing and endometrial safety.

Matched MeSH terms: Pressure Ulcer/etiology

Fulltext Extensive lip ulcers: a case report. Erythema multiforme

Chean KY

Aust Fam Physician, 2014 Jul;43(7):443-4.

PMID: 25006604

Matched MeSH terms: Ulcer/etiology

Fulltext Adult Bochadalek hernia complicated with perforated gastric ulcer: preoperative diagnosis with multiplanar CT

Faizah MZ, Sharifah MI, Johoruddin K, Juliana AL

Med J Malaysia, 2011 Oct;66(4):367-8.

PMID: 22299562 MyJurnal

Matched MeSH terms: Stomach Ulcer/etiology*

Fulltext A skin lesion and fever of unknown origin - a case study

Wong S, Ng CJ

Aust Fam Physician, 2012 Jan-Feb;41(1-2):41-4.

PMID: 22276283

Matched MeSH terms: Skin Ulcer/etiology*

Fulltext Contact lens--related corneal ulcer: a two-year review

Goh PP, Shamala R, Chandamalar S, Tai XY, National Eye Database Study Group

Med J Malaysia, 2010 Jun;65 Suppl A:120-3.

PMID: 21488471

To create a national registry of contact-lens related corneal ulcers (CLRCU) patients in Malaysia with the aim of detecting outbreaks, identifying pattern of causative organisms, determining patient demography, risk factors, wearing patterns and monitoring outcome of treatment. The CLRCU registry is an ongoing patient registry established in 2007 as a surveillance tool used by Malaysian Ministry of Health ophthalmology departments. Notification of patients clinically suspected of CLRCU was performed online through the National Eye Database (NED). Data collected included patient demography, contact lens type, causative organism and treatment outcome. During 2007-2008, a total of 202 patients were notified to the CLRCU registry with a mean age of 26.7 years (71.8% female). All registered patients wore soft contact lens and monthly disposable lenses were the most popular (83.5%). The majority of patients had bacterial CLRCU and the most common causative organism was Pseudomonas (79.7% of bacterial cases). No epidemics were identified during the period of data examination. Use of contact lenses, which is increasing during modern times, may lead to CLRCU as a severe complication. The CLRCU registry is an effective tool which uses a web-based notification system that allows quick and up to date reports of CLRCU cases. This provides the ability to monitor outbreaks of disease and identify important causative and associated factors of the disease which may be used to reduce future incidence.

Matched MeSH terms: Corneal Ulcer/etiology*

Histiocytosis X and vulvar ulceration

Wong KK, Lin HP, Looi LM

Int J Gynaecol Obstet, 1992 Oct;39(2):131-4.

PMID: 1358712

Vulvar ulceration is a rare manifestation of histiocytosis X. A 13-year-old girl had a nonhealing vulvar ulcer for 1 year. She had been in remission from histiocytosis X and the ulcer was not recognised as a sign of disease recurrence until tissue biopsy was obtained for histopathological and immunohistochemical studies. This article stresses the importance of establishing an accurate diagnosis when chronic vulvar ulcers are encountered and reviews the literature on this uncommon presentation of histiocytosis X.

Matched MeSH terms: Skin Ulcer/etiology*

Actinomycetic corneal ulcer

Singh M, Kaur B

Eye (Lond), 1989;3 ( Pt 4):460-2.

PMID: 2606221

A rare case of keratoactinomycosis developing in the absence of any known ocular trauma is described. It showed a dramatic response to penicillin therapy. Steroids should be cautiously used in the presence of active corneal disease. This case highlights the importance of repeated examination of corneal scrapings.

Matched MeSH terms: Corneal Ulcer/etiology*

Subcutaneous mycosis presenting as a non- healing left calf ulcer in an immunocompromised patient

Tang ASO, Yong KY, Wong J, Chua HH, Chew LP

Med J Malaysia, 2017 04;72(2):122-123.

PMID: 28473676

This is a case report of subcutaneous mycosis presenting as a non-healing left calf ulcer in an immunocompromised patient. Traumatic inoculation of the causative agent is the most likely route of infection. The diagnosis requires a detailed history and high clinical suspicion, confirmed by histopathological examination. The management requires a multidisciplinary team approach involving surgeon, pathologist, physician sub-specialised in infectious disease, wound care nursing team as well as social support services. The literature review recommended that the treatment of choice for such infection is surgical debridement in addition to optimal antifungal therapy.

Matched MeSH terms: Skin Ulcer/etiology

Fulltext Foot ulcers and their association with diabetic Charcot foot complications

Rahman NA, Fauzi AA, Chung TY, Latif LA, Chan SC

Aust J Gen Pract, 2020 2 3;49(1-2):48-53.

PMID: 32008261 DOI: 10.31128/AJGP-07-19-4991

BACKGROUND AND OBJECTIVES: Diabetic Charcot foot (DCF) can cause gross structural deformities of the foot and ankle. The main objective of this study was to identify complications of DCF and its associated factors.

METHOD: This is a retrospective cohort study. Data on medical background, previous DCF treatment and complications were obtained. Multiple logistic regression analysis was performed to measure factors related to various complications of DCF.

RESULTS: Ninety-eight patient records were retrieved. Of the 83 patients who were still alive, 75.9% (n = 63) had recurrent ulcers, 53.0% (n = 44) had undergone foot surgery and 45.8% (n = 38) had undergone amputation. Patients with a history of recurrent ulcers have the highest predilection to amputation (odds ratio: 8.5; 95% confidence interval: 1.8, 39.1).

DISCUSSION: In terms of DCF complications, foot ulcers are an independent predictor of recurrent foot ulcers, foot surgery and amputation. Regular foot assessment of patients with DCF to prevent ulcers is strongly recommended.

Matched MeSH terms: Foot Ulcer/etiology

Fulltext Sézary syndrome in a Malay--case report and literature review

Yuen P, Chan HL, Lee YS

Singapore Med J, 2001 May;42(5):224-7.

PMID: 11513062

Sézary syndrome is a rare form of primary cutaneous T cell lymphoma. It is a distinct systemic variant of mycosis fungoides, marked by erythroderma, lymphadenopathy and circulating cerebriform lymphocytes in the peripheral blood. We report a case of Sézary syndrome in a 61-year-old Malay man with a five-year history of indurated plaques, ulcers and tumours on the head and trunk, with characteristic findings on physical examination, skin biopsy, electron microscopy, immunophenotyping and peripheral blood film. A literature review on Sézary syndrome is presented.

Matched MeSH terms: Skin Ulcer/etiology

Elective proximal lower limb amputation in spinal cord injury patients with chronic pressure ulcers: improve quality of life, function, and shorten hospital stay. Case report

Yusmido YA, Hisamud-Din N, Mazlan M

Eur J Phys Rehabil Med, 2014 Oct;50(5):557-60.

PMID: 24694951

Pressure ulcers are common among patients with spinal cord injury and can be very challenging to treat. The treatment involves multidisciplinary approach and ranges from simple pressure relieve and wound dressings to a more radical treatment like proximal lower limb amputations, especially in chronic cases with potential detrimental effects to physical and mental health.

Matched MeSH terms: Pressure Ulcer/etiology

Bilateral simultaneous infectious keratitis secondary to contact lens wear: an unusual case report with rare organisms

Ali NA, Reddy SC

Eye Contact Lens, 2007 Nov;33(6 Pt 1):338-40.

PMID: 17993833

PURPOSE: To report an unusual case of bilateral simultaneous hypopyon corneal ulcer in a contact lens wearer caused by polymicrobial infection with rare organisms.
METHODS: A case report of a 21-year-old soft contact lens wearer, who visited the emergency department with a 3-day history of pain, redness, decreased vision, photophobia, and tearing in both eyes. Examination showed a central corneal ulcer with hypopyon in both eyes. The cultures from corneal scrapings of both eyes, the contact lenses, and the contact lens solution showed heavy growth of Pseudomonas aeruginosa, Alkaligenes species, and Flavobacterium meningosepticum.
RESULTS: The corneal ulcers healed completely with aggressive antibiotic treatment for 4 weeks. The best-corrected visual acuity after 6 months of follow-up was 20/400 in the right eye and 20/60 in the left eye.
CONCLUSIONS: The possibility of infectious keratitis should be kept in mind for an acute red eye in contact lens wearers, and appropriate initial management is essential for a successful outcome. It is believed that this is the first report of Flavobacterium meningosepticum as a causative organism in contact lens-related keratitis.

Matched MeSH terms: Corneal Ulcer/etiology

Fulltext Marjolin's ulcer--a near forgotten entity

Tan BC, Horton TC, Sara Ahmad T

Med J Malaysia, 2006 Feb;61 Suppl A:91-3.

PMID: 17042239

We report a case of a 55-year-old man who presented with a 6-month history of a fungating ulcer on the right hand at the site of a previously healed ulcer that had been present for 40 years. Histopathological examination of four-quadrant biopsy specimens showed a moderately differentiated squamous cell carcinoma (SCC). A transradiocarpal amputation with stump closure using radial flap was performed as it was not possible to achieve a functionally and cosmetically acceptable hand after a wide excision with 2 cm tumour-free margin. It is our intention to highlight this rare condition as reminder to consider this entity as a differential diagnosis of chronic non-healing skin ulcer.

Matched MeSH terms: Skin Ulcer/etiology

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