Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environmentally-induced diseases. It is therefore useful to further study this polymorphism in Malays.
1. Debrisoquine hydroxylation phenotyping was carried out in 97 Chinese and 97 Malay healthy volunteers. 2. No poor metabolizer was found in the Chinese population. Using a metabolic ratio antimode of 10.0, two poor metabolizers were present amongst the Malays studied.
Although Malays shared an origin with Chinese, their evolution saw substantial divergences. Phenotyping studies suggested that they differed in CYP2D6 polymorphism, with higher PM prevalence but lesser right-shift for debrisoquine MRs.