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Fulltext Delayed chronic polyneuropathy following organophosphate poisoning: a case report

Low ET, Loh TG

Med J Malaysia, 1987 Jun;42(2):113-4.

A patient with organophosphate poisoning who survived the acute phase and subsequently developed delayed neuropathy is presented. The features of this form of delayed neuropathy are described and the implications in our local context discussed.

Matched MeSH terms: Peripheral Nervous System Diseases/chemically induced*

Non-Hodgkin's lymphoma with left suprascapular neuropathy on magnetic resonance imaging

Faridah Y, Abdullah BJ

Hong Kong Med J, 2003 Apr;9(2):134-6.

PMID: 12668827

Magnetic resonance imaging is gaining importance in the diagnosis of nerve and muscular disorders. The ability of magnetic resonance imaging to delineate the different muscles and the nerve in any plane has made the differentiation between the changes of neuropathy, denervation, and nerve entrapment possible. Although findings on magnetic resonance imaging are non-specific, their use, coupled with clinical symptoms and electromyographic findings, allow an accurate diagnosis to be made without resorting to invasive biopsies.

Matched MeSH terms: Peripheral Nervous System Diseases/chemically induced*

Adverse effects of cytotoxics-platinum agents

Selvaratnam G, Philips RH, Mohamed AK, Radzi A

Adverse Drug React Toxicol Rev, 1997 Aug;16(3):171-97.

PMID: 9512763

Matched MeSH terms: Peripheral Nervous System Diseases/chemically induced

Vincristine-induced peripheral neuropathy in survivors of childhood acute lymphoblastic leukaemia

Tay CG, Lee VWM, Ong LC, Goh KJ, Ariffin H, Fong CY

Pediatr Blood Cancer, 2017 Aug;64(8).

PMID: 28139029 DOI: 10.1002/pbc.26471

BACKGROUND: Vincristine, an essential component of childhood acute lymphoblastic leukaemia (ALL) therapeutic protocols, is associated with dose-dependent neurotoxicity, but its long-term morbidity in treated children has not been clearly elucidated. The aim of this study is to determine the prevalence of vincristine-induced peripheral neuropathy (VIPN) among Malaysian childhood ALL survivors and its impact on motor function and quality of life.

PROCEDURE: Survivors of childhood ALL aged 4-18 years who had completed chemotherapy for 2 years or more were evaluated for VIPN using both the clinical Total Neuropathy Score (cTNS) and nerve conduction studies. Motor function and quality of life of the survivors were assessed via the Bruininks-Oseretsky Test of Motor Proficiency Brief Form, Second Edition (BOT-2 Brief Form) and the Paediatric Quality of Life version 4.0 Generic Core Scales (PedsQL4.0) questionnaire, respectively.

RESULTS: One hundred and one survivors with a duration of follow-up ranging from 2.0 to 10.3 years were recruited. Twenty-seven (26.7%) had abnormal cTNS scores and 69 (68.3%) had electrophysiological evidence of neuropathy. Of these, 16 (15.8%) had combined clinical and electrophysiological neuropathy (VIPN). Those previously treated on the intermediate- or high-risk treatment stratification arms had a higher risk of developing VIPN (67.3 vs. 32.7%; odds ratio [OR]: 9.06, 95% confidence interval [CI]: 1.14-71.86; P = 0.014). Survivors with VIPN had significantly lower quality of life scores in the physical (P = 0.024) and social domains (P = 0.039) compared with peers without VIPN, but no association with poorer motor function was observed.

CONCLUSIONS: Sixteen percent of ALL survivors had VIPN. VIPN should be increasingly recognised as a late effect of chemotherapy, as it significantly affects physical and social function quality of life.

Matched MeSH terms: Peripheral Nervous System Diseases/chemically induced*

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