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Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol

Shaw P 1 , Raymond G 2 , Senthilnathan R 3 , Kumarasamy C 4 , Baxi S 5 , Suresh D 6 Show all authors , Shetty S 7 , Ram M R 8 , Chandramoorthy HC 9 , Sivanandy P 10 , Samiappan S 11 , Rajagopal M 8 , Krishnan S 12 , Jayaraj R 13

Affiliations 

  • 1 Department of Artificial Intelligence, Nanjing University of Information Science and Technology (NUIST), Nanjing 210044, China
  • 2 Northern Territory Medical Program, CDU Campus, Flinders University, Ellengowan Drive, Darwin, NT 0909, Australia
  • 3 School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, India
  • 4 Kumarasamy School of Health and Medical Sciences, Curtin University, Perth, WA 6102, Australia
  • 5 MBBS, FRANZCR GAICD (SB), Genesis Care Gold Coast Radiation Oncologist, Southport, QLD 4224, Australia
  • 6 Division of Endocrinology, Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, FL 32224, USA
  • 7 Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Mangalore, Academy of Higher Education, A Constituent of MAHE, Manipal 576104, India
  • 8 Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University Kuala Lumpur (South Wing), No.1, Jalan Menara Gading, UCSI Heights 56000 Cheras, Kuala Lumpur 57000, Malaysia
  • 9 Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia
  • 10 Department of Pharmacy Practice, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia
  • 11 Department of Biochemistry, Bharathiar University, Coimbatore 641046, India
  • 12 Department of Radiation Oncology, Mayo Clinic Florida, 4500 San Pablo Road S., Jacksonville, FL 32224, USA
  • 13 Northern Territory Institute of Research and Training, Darwin, NT 0909, Australia
Genes (Basel), 2021 Dec 20;12(12).
PMID: 34946979 DOI: 10.3390/genes12122029

Abstract

Background: The microRNAs (miRNAs) are small noncoding single-stranded RNAs typically 19-25 nucleotides long and regulated by cellular and epigenetic factors. These miRNAs plays important part in several pathways necessary for cancer development, an altered miRNA expression can be oncogenic or tumor-suppressive. Recent experimental results on miRNA have illuminated a different perspective of the molecular pathogenesis of head and neck cancers. Regulation of miRNA can have a detrimental effect on the efficacy of chemotherapeutic drugs in both neoadjuvant and adjuvant settings. This miRNA-induced chemoresistance can influence the prognosis and survival rate. The focus of the study is on how regulations of various miRNA levels contribute to chemoresistance in head and neck cancer (HNC). Recent findings suggest that up or down-regulation of miRNAs may lead to resistance towards various chemotherapeutic drugs, which may influence the prognosis. Methods: Studies on miRNA-specific chemoresistance in HNC were collected through literary (bibliographic) databases, including SCOPUS, PubMed, Nature, Elsevier, etc., and were systematically reviewed following PRISMA-P guidelines (Preferred Reporting Items for Systematic Review and Meta-analysis Protocol). We evaluated various miRNAs, their up and downregulation, the effect of altered regulation on the patient's prognosis, resistant cell lines, etc. The data evaluated will be represented in the form of a review and meta-analysis. Discussion: This meta-analysis aims to explore the miRNA-induced chemoresistance in HNC and thus to aid further researches on this topic. PROSPERO registration: CRD42018104657.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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