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Interpreting biomonitoring data: Introducing the international human biomonitoring (i-HBM) working group's health-based guidance value (HB2GV) dashboard

Nakayama SF 1 , St-Amand A 2 , Pollock T 3 , Apel P 4 , Bamai YA 5 , Barr DB 6 Show all authors , Bessems J 7 , Calafat AM 8 , Castaño A 9 , Covaci A 10 , Duca RC 11 , Faure S 12 , Galea KS 13 , Hays S 14 , Hopf NB 15 , Ito Y 16 , Jeddi MZ 17 , Kolossa-Gehring M 18 , Kumar E 19 , LaKind JS 20 , López ME 21 , Louro H 22 , Macey K 23 , Makris KC 24 , Melnyk L 25 , Murawski A 26 , Naiman J 27 , Nassif J 28 , Noisel N 29 , Poddalgoda D 30 , Quirós-Alcalá L 31 , Rafiee A 32 , Rambaud L 33 , Silva MJ 34 , Ueyama J 35 , Verner MA 36 , Waras MN 37 , Werry K 38

Affiliations 

  • 1 Exposure Dynamics Research Section, Health and Environmental Risk Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, 305-8506, Japan. Electronic address: fabre@nies.go.jp
  • 2 Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave W, A/L 4908D, Ottawa, ON, K1A 0K9, Canada. Electronic address: annie.st-amand@hc-sc.gc.ca
  • 3 Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave W, A/L 4908D, Ottawa, ON, K1A 0K9, Canada. Electronic address: tyler.pollock@hc-sc.gc.ca
  • 4 German Environment Agency, Berlin/ Dessau-Roßlau, Wörlitzer Platz 1, 06844, Dessau-Roßlau, Germany. Electronic address: petra.apel@uba.de
  • 5 Center for Environmental and Health Sciences, Hokkaido University, Kita12, Nishi 7, Kita-ku, Sapporo, Japan. Electronic address: u-aitbamai@med.hokudai.ac.jp
  • 6 Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA, 30322, USA. Electronic address: dbbarr@emory.edu
  • 7 VITO NV, Boeretang 200, 2400, Mol, Belgium. Electronic address: jos.bessems@vito.be
  • 8 National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, USA. Electronic address: aic7@cdc.gov
  • 9 National Center for Environmental Health, Instituto de Salud Carlos III, 28220, Majadahonda, Madrid, Spain. Electronic address: castano@isciii.es
  • 10 Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address: adrian.covaci@uantwerpen.be
  • 11 Unit Environmental Hygiene and Human Biological Monitoring, Department of Health Protection, Laboratoire national de santé, 1, Rue Louis Rech, L-3555, Dudelange, Luxembourg. Electronic address: radu.duca@lns.etat.lu
  • 12 Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave W, A/L 4908D, Ottawa, ON, K1A 0K9, Canada. Electronic address: sarah.faure@hc-sc.gc.ca
  • 13 Institute of Occupational Medicine (IOM), Research Avenue North, Riccarton, Edinburgh, EH14 4AP, UK. Electronic address: karen.galea@iom-world.org
  • 14 Summit Toxicology LLP, 615 Nikles Dr., Unit 102, Bozeman, MT, 59715, USA. Electronic address: shays@summittoxicology.com
  • 15 Center for Primary Care and Public Health, Route de la Corniche 2, 1066, Epalinges-Lausanne, Switzerland. Electronic address: nancy.hopf@unisante.ch
  • 16 Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan. Electronic address: yukey@med.nagoya-cu.ac.jp
  • 17 National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven, the Netherlands. Electronic address: maryam.zare.jeddi@rivm.nl
  • 18 German Environment Agency, Berlin/ Dessau-Roßlau, Wörlitzer Platz 1, 06844, Dessau-Roßlau, Germany. Electronic address: marike.kolossa@uba.de
  • 19 Department of Health Security, Finnish Institute for Health and Welfare, Neulaniementie 4, FI-70210, Kuopio, Finland. Electronic address: eva.kumar@thl.fi
  • 20 LaKind Associates, LLC, 106 Oakdale Avenue, Catonsville, MD, 21228, USA; Department of Epidemiology and Public Health, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD, 21201, USA. Electronic address: lakindassoc@gmail.com
  • 21 National Center for Environmental Health, Instituto de Salud Carlos III, 28220, Majadahonda, Madrid, Spain. Electronic address: m.esteban@isciii.es
  • 22 Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge (INSA), Av. Padre Cruz 1649-016 Lisbon, and Center for Toxicogenomics and Human Health (ToxOmics), NOVA Medical School-FCM, UNL, Rua Câmara Pestana, 6 Ed. CEDOC II, 1150-082, Lisbon, Portugal. Electronic address: henriqueta.louro@insa.min-saude.pt
  • 23 Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave W, Ottawa, ON, K1A 0K9, Canada. Electronic address: kristin.macey@hc-sc.gc.ca
  • 24 Cyprus International Institute for Environmental and Public Health, School of Health Sciences, Cyprus University of Technology, Irinis 95, 3041, Limassol, Cyprus. Electronic address: konstantinos.makris@cut.ac.cy
  • 25 U.S. Environmental Protection Agency, Office of Research and Development/Center for Public Health and Environmental Assessment, 26 West Martin Luther King Drive, Cincinnati, OH, 45268, USA. Electronic address: Melnyk.lisa@epa.gov
  • 26 German Environment Agency, Berlin/ Dessau-Roßlau, Wörlitzer Platz 1, 06844, Dessau-Roßlau, Germany. Electronic address: aline.murawski@uba.de
  • 27 LaKind Associates, LLC, 504 S 44th St, Philadelphia, PA, 19104, USA. Electronic address: joshnaiman@gmail.com
  • 28 Association of Public Health Laboratories 8515 Georgia Avenue, Suite 700, Silver Spring, MD, 20910, USA. Electronic address: julianne.nassif@aphl.org
  • 29 Department of Occupational and Environmental Health, School of Public Health, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montreal, Quebec, H3C 3J7, Canada. Electronic address: nolwenn.noisel@umontreal.ca
  • 30 Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave W, Ottawa, ON, K1A 0K9, Canada. Electronic address: devika.poddalgoda@hc-sc.gc.ca
  • 31 Department of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA. Electronic address: lalcala1@jhu.edu
  • 32 Department of Medicine, University of Alberta, 173B Heritage Medical Research Centre, 11207 - 87 Ave NW, Edmonton, AB, T6G 2S2, Canada. Electronic address: rafieeta@ualberta.ca
  • 33 Occupational and Environmental Health Division, Santé publique France, 12 rue du Val d'Osne, 94415, Saint-Maurice, France. Electronic address: Loic.Rambaud@santepubliquefrance.fr
  • 34 Human Genetics Department, National Institute of Health Doutor Ricardo Jorge, Avenida Padre Cruz, 1649-016, Lisboa, Portugal. Electronic address: M.Joao.Silva@insa.min-saude.pt
  • 35 Department of Biomolecular Sciences, Field of Omics Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan. Electronic address: ueyama@met.nagoya-u.ac.jp
  • 36 Department of Occupational and Environmental Health, School of Public Health, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montreal, Quebec, H3C 3J7, Canada. Electronic address: marc-andre.verner.1@umontreal.ca
  • 37 Toxicology Department, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, P. Pinang, Malaysia. Electronic address: maisarah.waras@usm.my
  • 38 Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave W, A/L 4908D, Ottawa, ON, K1A 0K9, Canada. Electronic address: kate.werry@canada.ca
Int J Hyg Environ Health, 2023 Jan;247:114046.
PMID: 36356350 DOI: 10.1016/j.ijheh.2022.114046

Abstract

Human biomonitoring (HBM) data measured in specific contexts or populations provide information for comparing population exposures. There are numerous health-based biomonitoring guidance values, but to locate these values, interested parties need to seek them out individually from publications, governmental reports, websites and other sources. Until now, there has been no central, international repository for this information. Thus, a tool is needed to help researchers, public health professionals, risk assessors, and regulatory decision makers to quickly locate relevant values on numerous environmental chemicals. A free, on-line repository for international health-based guidance values to facilitate the interpretation of HBM data is now available. The repository is referred to as the "Human Biomonitoring Health-Based Guidance Value (HB2GV) Dashboard". The Dashboard represents the efforts of the International Human Biomonitoring Working Group (i-HBM), affiliated with the International Society of Exposure Science. The i-HBM's mission is to promote the use of population-level HBM data to inform public health decision-making by developing harmonized resources to facilitate the interpretation of HBM data in a health-based context. This paper describes the methods used to compile the human biomonitoring health-based guidance values, how the values can be accessed and used, and caveats with using the Dashboard for interpreting HBM data. To our knowledge, the HB2GV Dashboard is the first open-access, curated database of HBM guidance values developed for use in interpreting HBM data. This new resource can assist global HBM data users such as risk assessors, risk managers and biomonitoring programs with a readily available compilation of guidance values.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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