Affiliations 

  • 1 Saw Swee Hock School of Public Health, National University of Singapore, MD3 16 Medical Drive, Singapore 117597, Singapore. statyy@nus.edu.sg
BMC Genomics, 2014;15:332.
PMID: 24885517 DOI: 10.1186/1471-2164-15-332

Abstract

The HUGO Pan-Asian SNP Consortium (PASNP) has generated a genetic resource of almost 55,000 autosomal single nucleotide polymorphisms (SNPs) across more than 1,800 individuals from 73 urban and indigenous populations in Asia. This has offered valuable insights into the correlation between the genetic ancestry of these populations with major linguistic systems and geography. Here, we attempt to understand whether adaptation to local climate, diet and environment partly explains the genetic variation present in these populations by investigating the genomic signatures of positive selection.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.