The longitudinal course of pediatric acute respiratory distress syndrome and its time to resolution: A prospective observational study

Wong JJM 1 , Tan HL 1 , Sultana R 2 , Ma YJ 3 , Aguilan A 1 , Lee SW 4 Show all authors , Kumar P 5 , Mok YH 1 , Lee JH 1

Affiliations 

  • 1 Children's Intensive Care Unit, Department of Pediatric Subspecialties, KK Women's and Children's Hospital, Singapore, Singapore
  • 2 Center for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore
  • 3 Duke-NUS Medical School, Singapore, Singapore
  • 4 Pediatric Intensive Care Unit, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia
  • 5 Translational Immunology Institute, SingHealth/Duke-NUS Academic Medical Centre, Singapore, Singapore
Front Pediatr, 2022;10:993175.
PMID: 36483473 DOI: 10.3389/fped.2022.993175

Abstract

BACKGROUND: The longitudinal course of patients with pediatric acute respiratory distress syndrome (PARDS) is not well described. In this study, we describe the oxygenation index (OI) and oxygen saturation index (OSI) in mild, moderate, and severe PARDS over 28 days and provide pilot data for the time to resolution of PARDS (T res), as a short-term respiratory-specific outcome, hypothesizing that it is associated with the severity of PARDS and clinical outcomes.

METHODS: This prospective observational study recruited consecutive patients with PARDS. OI and OSI were trended daily over 28 days. T res (defined as OI 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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