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COL1A1 and FGFR2 Single-Nucleotide Polymorphisms Found in Class II and Class III Skeletal Malocclusions in Javanese Population

Ardani IGAW 1 , Budipramana M 2 , Rachmawati E 1 , Nugraha AP 1 , Ardana IKKG 3 , Budhy TI 4 Show all authors , Hassan R 5 , Listyorini D 6 , Sarno R 7

Affiliations 

  • 1 Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
  • 2 Department of Orthodontics, Faculty of Dental Medicine, Universitas Lambung Mangkurat, Banjarmasin, Indonesia
  • 3 Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia
  • 4 Department of Oral and Maxillofacial Pathology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
  • 5 Orthodontic Unit, School of Dental Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
  • 6 Department of Biotechnology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia
  • 7 Department of Informatics, Institute Technology of Sepuluh Nopember, Surabaya, Indonesia
Eur J Dent, 2023 Feb;17(1):183-190.
PMID: 35672017 DOI: 10.1055/s-0042-1744371

Abstract

OBJECTIVE:  The aim of this article is to analyze and compare the presence of single-nucleotide polymorphisms (SNPs) of COL1A1 and FGFR2 in class II and class III Javanese populations.

MATERIALS AND METHODS:  Cephalometric radiographs from total 63 patients of class II and III were analyzed. SNP analysis was performed based on both COL1A1 and FGFR2 sequences amplified from total DNA of patients' fresh blood. Principal component analysis was done to calculate the data and find the correlation of the cephalometric indicators influenced by each mutation. t-test and Mann-Whitney analysis were performed to check the significance of differences occurred in each studied parameter (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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