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COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure

Pironi L 1 , Jezerski D 2 , Sobocki J 3 , Lal S 4 , Vanuytsel T 5 , Theilla M 6 Show all authors , Sasdelli AS 7 , Chambrier C 8 , Matysiak K 9 , Aimasso U 10 , Rasmussen HH 11 , Jukes A 12 , Kunecki M 13 , Seguy D 14 , Schneider SM 15 , Daniels J 16 , Poullenot F 17 , Mundi MS 18 , Matras P 19 , Folwarski M 20 , Crivelli A 21 , Wyer N 22 , Ellegard L 23 , Santarpia L 24 , Arvanitakis M 25 , Spaggiari C 26 , Lamprecht G 27 , Guglielmi FW 28 , Lezo A 29 , Layec S 30 , Boluda ER 31 , Guz-Mark A 32 , Gandullia P 33 , Cuerda C 34 , Osland E 35 , Spagnuolo MI 36 , Krznaric Z 37 , Masconale L 38 , Chapman B 39 , Maíz-Jiménez M 40 , Orlandoni P 41 , Martins da Rocha MH 42 , Virgili-Casas MN 43 , Doitchinova-Simeonova M 44 , Czako L 45 , Van Gossum A 46 , D'Antiga L 47 , Ee LC 48 , Warodomwichit D 49 , Taus M 50 , Kolaček S 51 , Thibault R 52 , Verlato G 53 , Serralde-Zúñiga AE 54 , Botella-Carretero JI 55 , Aguayo PS 56 , Olveira G 57 , Chomtho S 58 , Pisprasert V 59 , Moisejevs G 60 , Murillo AZ 61 , Jáuregui MEP 62 , Díez MB 63 , Jahit MS 64 , Densupsoontorn N 65 , Tamer A 66 , Brillanti G 67 , Joly F 68

Affiliations 

  • 1 University of Bologna, Department of Medical and Surgical Sciences, Italy; Centre for Chronic Intestinal Failure, Clinical Nutrition and Metabolism Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy. Electronic address: loris.pironi@unibo.it
  • 2 Home Nutrition Support, Cleveland Clinic Foundation, Cleveland, OH, USA
  • 3 Centre of Postgraduate Medical Education, Warsaw, Poland
  • 4 Intestinal Failure Unit, Salford Royal Foundation Trust, Salford, UK
  • 5 University Hospital Leuven, Leuven Intestinal Failure and Transplantation (LIFT), Leuven, Belgium
  • 6 Rabin Medical Center, Petach Tikva, Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yaffo Academic College School for Nursing Sciences, Israel
  • 7 Centre for Chronic Intestinal Failure, Clinical Nutrition and Metabolism Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy
  • 8 Unité de Nutrition Clinique Intensive, Hospices Civils de Lyon, Hôpital Lyon Sud, Lyon, France
  • 9 Centre for Intestinal Failure, Department of General, Endocrinological and Gastroenterological Surgery, Poznań University of Medical Science, Poznań, Poland
  • 10 Città della Salute e della Scienza, Turin, Italy
  • 11 Centre for Nutrition and Bowel Disease, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark
  • 12 University Hospital of Wales, Cardiff, United Kingdom
  • 13 M. Pirogow Hospital, Lodz, Poland
  • 14 Service de Nutrition, CHRU de Lille, Lille, France
  • 15 Gastroenterology and Clinical Nutrition, CHU of Nice, Université Côte d'Azur, Nice, France
  • 16 Nottingham University Hospital NHS Trust, Nottingham, United Kingdom
  • 17 Service de Gastroentérologie, Hôpital Haut-Lévêque, CHU de Bordeaux, Pessac, France
  • 18 Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, MN, USA
  • 19 Department of General and Transplant Surgery and Clinical Nutrition, Medical University of Lublin, Lublin, Poland
  • 20 Department of Clinical Nutrition and Dietetics, Medical University of Gdansk, Home Enteral and Parenteral Nutrition Unit, Copernicus Hospital, Gdansk, Poland
  • 21 Unidad de Soporte Nutricional, Rehabilitación y Trasplante de Intestino, Hospital Universitario Fundacion Favaloro, Buenos Aires, Argentina
  • 22 University Hospitals Coventry & Warwickshire NHS Trust, Coventry, United Kingdom
  • 23 Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
  • 24 Internal Medicine and Clinical Nutrition Unit, Federico II University, Naples, Italy
  • 25 Department of Gastroenterology, HUB Erasme, Brussels, Belgium
  • 26 AUSL Parma, Parma, Italy
  • 27 University Medical Center Rostock, Rostock, Germany
  • 28 Gastroenterology Unit, Monsignor di Miccoli Hospital, Barletta, Italy
  • 29 Department of Clinical Nutrition, OIRM-S. Anna Hospital, Città della Salute e della Scienza, Turin, Italy
  • 30 Digestive and Nutritional Rehabilitation Unit/Artificial Nutrition Unit, Clinique Saint-Yves, Rennes, France
  • 31 Pediatric Gastrointestinal and Nutrition Unit, University Hospital La Paz, Madrid, Spain
  • 32 Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach-Tikva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  • 33 Pediatric Gastroenterology and Endoscopy, IRCCS G. Gaslini Institute, Genoa, Italy
  • 34 University Complutense. Department of Medicine, Nutrition Unit, Hospital General Universitario Gregorio Marañon, Madrid, Spain
  • 35 Royal Brisbane and Women's Hospital, Herston, Australia
  • 36 Section of Paediatrics, Department of Translational Medical Science, University of Naples Federico II, Naples, Italy
  • 37 Centre of Clinical Nutrition, Department of Medicine, University Hospital Centre, Zagreb, Croatia
  • 38 Ospedale Orlandi, Bussolengo (VR), Italy
  • 39 Austin Health, Melbourne, Australia
  • 40 Department of Endocrinology and Nutrition, Hospital 12 de Octubre, Madrid, Spain
  • 41 Nutrizione Clinica-Centro di Riferimento Regionale NAD, IRCCS-INRCA, Ancona, Italy
  • 42 Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
  • 43 Department of Endocrinology and Nutrition, Hospital Universitari de Bellvitge, Barcelona, Spain
  • 44 Bulgarian Association of Patients with Malnutrition, Sofia, Bulgaria
  • 45 First Department of Internal Medicine, Szeged, Hungary
  • 46 Department of Gastroenterology, HUB Erasme, Brussels
  • 47 Paediatric Hepatology, Gastroenterology and Transplantation. "Papa Giovanni XXIII" Hospital, Bergamo, Italy
  • 48 Queensland Children's Hospital, Brisbane, Australia
  • 49 Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • 50 SOD Dietetica e Nutrizione Clinica, Centro Riferimento Regionale NAD, Ospedali Riuniti di Ancona, Italy
  • 51 Children's Hospital Zagreb, Zagreb Medical University, Zagreb, Croatia
  • 52 CHU Rennes, Nutrition Unit, Home Parenteral Nutrition Centre, INRAE, INSERM, Univ Rennes, Nutrition Metabolisms and Cancer, NuMeCan, Rennes, France
  • 53 Paediatric Nutrition Service-Neonatal Intensive Care Unit, University Hospital of Padova, Padova, Italy
  • 54 Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, México, Mexico
  • 55 Department of Endocrinology and Nutrition-Hospital Universitario Ramón y Cajal, & IRyCIS Madrid, Spain
  • 56 Hospital Universitario Virgen del Rocío, Sevilla, Spain
  • 57 Hospital Regional Universitario de Málaga, IBIMA, Universidad de Málaga, Spain
  • 58 Pediatric Nutrition Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Division of Nutrition, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
  • 59 Division of Clinical Nutrition, Department of Medicine, Khon Kaen University, Srinagarind Hospital, Khon Kaen, Thailand
  • 60 Riga East University Hospital, Riga, Latvia
  • 61 Hospital Virgen del Camino, Pamplona, Spain
  • 62 Complejo Hospitalario de Navarra, Pamplona, Spain
  • 63 Hospital Universitari Arnau de Vilanova, Lleida, Spain
  • 64 National Cancer Institute/Institut Kanser Negara, Putrajaya Wilayah Persekutuan, Malaysia
  • 65 Division of Nutrition, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • 66 Internal Medicine, Sakarya Unıversity Medical Faculty Education and Research Hospital, Sakarya, Turkey
  • 67 University of Bologna, Department of Medical and Surgical Sciences, Italy
  • 68 Centre for Intestinal Failure, Department of Gastroenterology and Nutritional Support, Hôpital Beaujon, Clichy, France
Clin Nutr ESPEN, 2023 Jun;55:212-220.
PMID: 37202049 DOI: 10.1016/j.clnesp.2023.03.008

Abstract

BACKGROUND AND AIMS: To investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN).

METHODS: Period of observation: March 1st, 2020 March 1st, 2021.

INCLUSION CRITERIA: patients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up.

RESULTS: Sixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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