Fulltext

Comparison of the management of Helicobacter pylori infection between the older and younger European populations

Jonaitis P 1 , Nyssen OP 2 , Saracino IM 3 , Fiorini G 3 , Vaira D 3 , Pérez-Aísa Á 4 Show all authors , Tepes B 5 , Castro-Fernandez M 6 , Pabón-Carrasco M 6 , Keco-Huerga A 6 , Voynovan I 7 , Lucendo AJ 8 , Lanas Á 9 , Martínez-Domínguez SJ 9 , Almajano EA 9 , Rodrigo L 10 , Vologzanina L 11 , Brglez Jurecic N 12 , Denkovski M 12 , Bujanda L 13 , Mahmudov U 14 , Leja M 15 , Lerang F 16 , Babayeva G 17 , Bordin DS 7 , Gasbarrini A 18 , Kupcinskas J 1 , Gridnyev O 19 , Rokkas T 20 , Marcos-Pinto R 21 , Phull PS 22 , Smith SM 23 , Tonkić A 24 , Boltin D 25 , Buzás GM 26 , Šembera Š 27 , Şimşek H 28 , Matysiak-Budnik T 29 , Milivojevic V 30 , Marlicz W 31 , Venerito M 32 , Boyanova L 33 , Doulberis M 34 , Capelle LG 35 , Cano-Català A 36 , Moreira L 37 , Mégraud F 38 , O'Morain C 23 , Gisbert JP 39 , Jonaitis L 1 , Hp-EuReg investigators

Affiliations 

  • 1 Department of Gastroenterology, Lithuanian University of Health Sciences, 50161, Kaunas, Lithuania
  • 2 Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad Autónoma de Madrid (UAM), Diego de León, 62, 28006, Madrid, Spain. opn.aegredcap@aegastro.es
  • 3 Department of Surgical and Medical Sciences, IRCCS AOUBO, University of Bologna, 40138, Bologna, Italy
  • 4 Agencia Sanitaria Costa del Sol, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), 29651, Marbella, Spain
  • 5 Department of Gastroenterology, AM DC Rogaska, 3250, Rogaska Slatina, Slovenia
  • 6 Department of Gastroenterology, Hospital de Valme, 41014, Seville, Spain
  • 7 Department of Gastroenterology, A.S. Loginov Moscow Clinical Scientific Center, 111123, Moscow, Russia
  • 8 Department of Gastroenterology, Hospital General de Tomelloso, 13700, Tomelloso, Spain
  • 9 IIS Aragón y Facultad de Medicina de la Universidad de Zaragoza, 50009, Zaragoza, Spain
  • 10 Gastroenterology Unit, Hospital Universitario Central de Asturias, 33011, Oviedo, Spain
  • 11 Department of Gastroenterology, Gastrocentre, 614068, Perm, Russia
  • 12 Department of Gastroenterology, Interni Oddelek, Diagnostic Centre, 4260, Bled, Slovenia
  • 13 Hospital Donostia, Instituto Biodonostia, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), 20018, San Sebastián, Spain
  • 14 Modern Hospital, 1119, Baku, Azerbaijan
  • 15 Department of Gastroenterology, Digestive Diseases Centre Gastro, Institute of Clinical and Preventive Medicine and Faculty of Medicine, University of Latvia, Riga, 1079, Latvia
  • 16 Department of Gastroenterology, Østfold Hospital Trust, 1714, Grålum, Norway
  • 17 Memorial Klinik, 1096, Baku, Azerbaijan
  • 18 Medicina Interna, Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Università Cattolica del Sacro Cuore, 00168, Rome, Italy
  • 19 Government Institution "L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine", Kyiv, Ukraine
  • 20 Department of Gastroenterology, Henry Dunant Hospital, 115 26, Athens, Greece
  • 21 Department of Gastroenterology, Centro Hospitalar do Porto Institute of Biomedical Sciences Abel Salazar, Centro de Investigação em Tecnologias e Serviços de Saúde, University of Porto, 4050-313, Porto, Portugal
  • 22 Department of Gastroenterology, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN, UK
  • 23 Faculty of Health Sciences, Trinity College Dublin, Dublin, D02PN40, Ireland
  • 24 Department of Gastroenterology, University Hospital of Split, University of Split School of Medicine, 21000, Split, Croatia
  • 25 Division of Gastroenterology, Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, 49100, Tel Aviv, Israel
  • 26 Department of Gastroenterology, Ferencváros Health Centre, 1095, Budapest, Hungary
  • 27 2nd Department of Internal Medicine and Gastroenterology, University Hospital and Charles University, Faculty of Medicine in Hradec Králové, 500 03, Hradec Králové, Czech Republic
  • 28 Division of Gastroenterology and Hepatology, Hacettepe University School of Medicine, 06230, Ankara, Turkey
  • 29 Department of Gastroenterology, CHRU de Nantes, Hôpital Hôtel Dieu, 44000, Nantes, France
  • 30 Department of Gastroenterology, Clinical Center of Serbia, University of Belgrade School of Medicine, 11000, Belgrade, Serbia
  • 31 Department of Gastroenterology, Pomeranian Medical University, 70-204, Szczecin, Poland
  • 32 Department of Gastroenterology, Otto-Von-Guericke University, 39120, Magdeburg, Germany
  • 33 Department of Gastroenterology, Medical Microbiology, Medical University of Sofia, 1431, Sofia, Bulgaria
  • 34 Division of Gastroenterology and Hepatology, Medical University Department, Kantonsspital Aarau, 5001, Aarau, Switzerland
  • 35 Department of Gastroenterology, Meander Medical Center, 3813 TZ, Amersfoort, The Netherlands
  • 36 GOES Research Group, Althaia Xarxa Assistencial Universitària de Manresa, 08243, Manresa, Spain
  • 37 Department of Gastroenterology, Hospital Clínic Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), University of Barcelona, 08036, Barcelona, Spain
  • 38 INSERM U1312, Université de Bordeaux, 33000, Bordeaux, France
  • 39 Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad Autónoma de Madrid (UAM), Diego de León, 62, 28006, Madrid, Spain
Sci Rep, 2023 Oct 11;13(1):17235.
PMID: 37821503 DOI: 10.1038/s41598-023-43287-4

Abstract

The prevalence of Helicobacter pylori remains high in the older population. Specific age-related peculiarities may impact the outcomes of H. pylori treatment. The aim of the study was to evaluate the diagnostics and effectiveness of H. pylori eradication between the younger and older European populations. "European Registry on H. pylori Management (Hp-EuReg)" data from 2013 to 2022 were analyzed. Patients were divided into older (≥ 60 years) and younger (18-59 years) groups. Modified intention-to-treat (mITT) and per-protocol (PP) analysis was performed. 49,461 patients included of which 14,467 (29%) were older-aged. Concomitant medications and penicillin allergy were more frequent among the older patients. Differences between younger and older populations were observed in treatment duration in first-line treatment and in proton pump inhibitors (PPIs) doses in second-line treatment. The overall incidence of adverse events was lower in the older adults group. The overall first-line treatment mITT effectiveness was 88% in younger and 90% in the older patients (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications