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Role of compliance in Helicobacter pylori eradication treatment: Results of the European Registry on H. pylori management

Huguet JM 1 , Ferrer-Barceló L 1 , Suárez P 1 , Barcelo-Cerda S 2 , Sempere J 1 , Saracino IM 3 Show all authors , Fiorini G 3 , Vaira D 3 , Pérez-Aísa Á 4 , Jonaitis L 5 , Tepes B 6 , Castro-Fernandez M 7 , Pabón-Carrasco M 7 , Keco-Huerga A 7 , Voynovan I 8 , Lucendo AJ 9 , Lanas Á 10 , Martínez-Domínguez SJ 10 , Alfaro Almajano E 10 , Rodrigo L 11 , Vologzanina L 12 , Bordin DS 13 , Gasbarrini A 14 , Babayeva G 15 , Lerang F 16 , Leja M 17 , Kupčinskas J 5 , Rokkas T 18 , Marcos-Pinto R 19 , Meštrović A 20 , Gridnyev O 21 , Phull PS 22 , Smith SM 23 , Boltin D 24 , Buzás GM 25 , Kral J 26 , Şimşek H 27 , Matysiak-Budnik T 28 , Milivojevic V 29 , Marlicz W 30 , Venerito M 31 , Boyanova L 32 , Doulberis M 33 , Capelle LG 34 , Cano-Català A 35 , Moreira L 36 , Nyssen OP 37 , Mégraud F 38 , O'Morain C 23 , Gisbert JP 37 , Hp‐EuReg Investigators

Affiliations 

  • 1 Department of Gastroenterology, Hospital General Universitario de Valencia, Valencia, Spain
  • 2 Department of Applied Statistics and Operational Research, and Quality, Universitat Politècnica de Valencia, Valencia, Spain
  • 3 IRCCS S. Orsola Polyclinic, University of Bologna, Bologna, Italy
  • 4 Agencia Sanitaria Costa del Sol, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Marbella, Spain
  • 5 Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • 6 Department of Gastroenterology, AM DC Rogaska, Rogaska Slatina, Slovenia
  • 7 Unidad de Aparato Digestivo, Hospital Universitario de Valme, Sevilla, Spain
  • 8 Department of Gastroenterology, A.S. Loginov Moscow Clinical Scientific Center, Moscow, Russia
  • 9 Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain
  • 10 Servicio de Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
  • 11 Department of Gastroenterology, University of Oviedo, Oviedo, Spain
  • 12 Department of Gastroenterology, Gastrocentr, Perm, Russia
  • 13 Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, A. S. Loginov Moscow Clinical Scientific Center, Moscow, Russia
  • 14 Medicina interna e Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy
  • 15 Department of Therapy, Azerbaijan State Advanced Training Institute for Doctors Named After Aziz Aliyev, Baku, Azerbaijan
  • 16 Department of Gastroenterology, Østfold Hospital Trust, Grålum, Norway
  • 17 Department of Gastroenterology, Digestive Diseases Centre, Riga, Latvia
  • 18 Department of Gastroenterology, Henry Dunant Hospital, Athens, Greece
  • 19 Gastroenterology Department, Centro Hospitalar do Porto, Instituto De Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal
  • 20 Department of Gastroenterology, University Hospital of Split, University of Split School of Medicine, Split, Croatia
  • 21 Division for the Study of the Digestive Diseases and its Comorbidity with Noncommunicable Diseases, Government Institution L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine
  • 22 Department of Digestive Disorders, Aberdeen Royal Infirmary, Aberdeen, UK
  • 23 Faculty of Health Sciences, Trinity College Dublin, Dublin, Ireland
  • 24 Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel
  • 25 Department of Gastroenterology, Ferencváros Health Centre, Budapest, Hungary
  • 26 Hepatogastroenterology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
  • 27 Division of Gastroenterology and Hepatology, Hacettepe University School of Medicine, Ankara, Turkey
  • 28 Department of Gastroenterology, CHRU de Nantes, Hôpital Hôtel Dieu, Nantes, France
  • 29 Department of Gastroenterology, Clinical Center of Serbia, University of Belgrade School of Medicine, Belgrade, Serbia
  • 30 Department of Gastroenterology, Pomeranian Medical University in Szczecin, Szczecin, Poland
  • 31 Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany
  • 32 Department of Gastroenterology, Medical Microbiology, Medical University of Sofia, Sofia, Bulgaria
  • 33 Medical University Department, Division of Gastroenterology and Hepatology, Kantonsspital Aarau, Aarau, Switzerland
  • 34 Department of Gastroenterology and Hepatology, Meander Medical Center, Amersfoort, Netherlands
  • 35 GOES Research Group, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain
  • 36 Department of Gastroenterology, Hospital Clínic Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), University of Barcelona, Barcelona, Spain
  • 37 Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain
  • 38 INSERM U1312, Université de Bordeaux, Bordeaux, France
United European Gastroenterol J, 2024 Jul;12(6):691-704.
PMID: 38685613 DOI: 10.1002/ueg2.12569

Abstract

BACKGROUND: Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate treatment efficacy.

OBJECTIVE: To determine which factors influence compliance with treatment.

METHODS: A systematic prospective non-interventional registry (Hp-EuReg) of the clinical practice of European gastroenterologists. Compliance was considered adequate if ≥90% drug intake. Data were collected until September 2021 using the AEG-REDCap e-CRF and were subjected to quality control. Modified intention-to-treat analyses were performed. Multivariate analysis carried out the factors associated with the effectiveness of treatment and compliance.

RESULTS: Compliance was inadequate in 646 (1.7%) of 38,698 patients. The non-compliance rate was higher in patients prescribed longer regimens (10-, 14-days) and rescue treatments, patients with uninvestigated dyspepsia/functional dyspepsia, and patients reporting adverse effects. Prevalence of non-adherence was lower for first-line treatment than for rescue treatment (1.5% vs. 2.2%; p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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