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Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management

García-Morales N 1 , Pérez-Aísa Á 2 , Fiorini G 3 , Tepes B 4 , Castro-Fernández M 5 , Lucendo A 6 Show all authors , Voynovan I 7 , Bujanda L 8 , Garre A 9 , Rodrigo L 10 , Martínez Domínguez SJ 11 , Denkovski M 12 , Huguet Malavés JM 13 , Jonaitis L 14 , Bumane R 15 , Zaytsev O 16 , Mata Romero P 17 , Barrio J 18 , Fernández-Salazar L 19 , Sarsenbaeva AS 20 , Ortiz Polo I 21 , Alekseenko S 22 , Saracino IM 3 , Vaira D 3 , Keco-Huerga A 5 , Bordin D 23 , Gasbarrini A 24 , Lerang F 25 , Rokkas T 26 , Kupčinskas J 14 , Leja M 15 , Babayeva G 27 , Marcos Pinto R 28 , Tonkić A 29 , Smith S 30 , Phull P 31 , Buzas GM 32 , Simsek H 33 , Boltin D 34 , Gridnyev O 35 , Venerito M 36 , Milivojevic V 37 , Torà N 38 , Cano-Català A 38 , Moreira L 39 , Nyssen OP 9 , Mégraud F 40 , O'Morain C 41 , Gisbert JP 9 , Puig I 42 , On Behalf Of Hp-EuReg Investigators

Affiliations 

  • 1 Digestive Service, Complexo Hospitalario Universitario de Vigo, Sergas, South Galicia Health Research Institute, 36312 Vigo, Spain
  • 2 Unidad de Digestivo, Hospital Costa del Sol Marbella, Redes de Investigación Cooperativa Orientada a Resultados en Salud (RICORS), 29603 Marbella, Spain
  • 3 Department of Surgical and Medical Sciences, IRCCS AOU S. Orsola, 39015 Bologna, Italy
  • 4 AM DC Rogaska, 3250 Rogaska Slatina, Slovenia
  • 5 Hospital Valme, 41014 Sevilla, Spain
  • 6 Hospital de Tomelloso, 13700 Ciudad Real, Spain
  • 7 A.S. Loginov, Clinical Scientific Centre, 111123 Moscow, Russia
  • 8 Department of Gastroenterology, Biodonostia Health Research Institute, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), 20014 San Sebastián, Spain
  • 9 Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
  • 10 Hospital Central de Asturias, 33011 Oviedo, Spain
  • 11 Hospital Clínico Lozano Blesa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 50009 Zaragoza, Spain
  • 12 Diagnostic Center Bled, 4260 Bled, Slovenia
  • 13 Hospital General Universitario de Valencia, 46014 Valencia, Spain
  • 14 Department of Gastroenterology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
  • 15 Digestive Diseases Centre GASTRO, LV-1006 Riga, Latvia
  • 16 First Clinical Medical Centre, 601900 Kovrov, Russia
  • 17 Hospital Universitario de Cáceres, 10004 Cáceres, Spain
  • 18 Hospital Rio Hortega, 47012 Valladolid, Spain
  • 19 Hospital Clínico de Valladolid, 47003 Valladolid, Spain
  • 20 Gastroenterologist Department of Regional Clinical Hospital N3, 454080 Chelyabinsk, Russia
  • 21 Hospital la Fe, 46026 Valencia, Spain
  • 22 Far Eastern State Medical University, 680000 Khabarovsk, Russia
  • 23 Gastroenterology Unit, A.S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia
  • 24 Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
  • 25 Central Hospital of Ostfold, 1601 Fredrikstad, Norway
  • 26 Henry Dunant Hospital, 115 26 Athens, Greece
  • 27 Memorial Klinika, 1096 Baku, Azerbaijan
  • 28 Centro Hospitalario do Porto, 4050-101 Porto, Portugal
  • 29 Department Gastroenterol & Hepatol, University Hospital Centre Split, 2100 Split, Croatia
  • 30 Tallaght Hospital, DR24 NR0A Dublin, Ireland
  • 31 Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK
  • 32 Gastroenterology, Ferencváros Health Centre, Mester utca 45, 1095 Budapest, Hungary
  • 33 Internal Med Gastroenterol Department, Hacettepe University School of Medicine, 06230 Ankara, Turkey
  • 34 Division of Gastroenterology, Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv 4941492, Israel
  • 35 L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences, ID 70483 Kharkiv, Ukraine
  • 36 Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, 44, 39120 Magdeburg, Germany
  • 37 Clinical Center of Serbia, 11000 Belgrade, Serbia
  • 38 GOES Research Group, Unitat de Recerca i Innovació, Athaia Xarxa Assistencial Universitària de Manresa, 08243 Manresa, Spain
  • 39 Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERed), 08036 Barcelona, Spain
  • 40 INSERM U1312, Université de Bordeaux, 33000 Bordeaux, France
  • 41 Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
  • 42 Althaia Xarxa Assistencial Universitària de Manresa and Universitat de Vic-Universitat Central de Catalunya (UVicUCC), 08242 Manresa, Spain
J Clin Med, 2023 Jun 28;12(13).
PMID: 37445399 DOI: 10.3390/jcm12134363

Abstract

BACKGROUND AND AIMS: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe.

METHODS: The European Registry on the management of Helicobacter pylori infection is an international, multicentre, prospective, non-interventional registry aiming to evaluate the management of Helicobacter pylori-infected patients in Europe. Countries with at least 100 cases registered from June 2013 to April 2021, and with a validated diagnostic method were analysed. Data were quality reviewed.

RESULTS: A total of 34,920 adult patients from 20 countries were included (mean age 51 years; 61% women). To establish the initial diagnosis, invasive tests were performed in 19,801 (71%) patients, non-invasive in 11,369 (41%), and both in 3437 (12%). The most frequent were histology (n = 11,885; 43%), a rapid urease test (n = 10,636; 38%) and an urea breath test (n = 7577; 27%). According to the age, invasive tests were indicated in 11,179 (77%) ≥50 years, and in 8603 (65%) <50 years. Depending on the country, the use of invasive tests ranged from 29-99% in <50 years to 60-99% in ≥50. Most of the tests used to confirm eradication were non-invasive (n = 32,540; 93%), with the urea breath test being the most frequent (n = 32,540; 78%). In 2983 (9%) post-treatment tests, histology (n = 1887; 5%) or a rapid urease test (n = 1223; 4%) were performed.

CONCLUSION: A great heterogeneity was observed for the initial diagnosis and confirmation of the eradication. The reasons for the apparent lack of adherence to the clinical guidelines should be further explored.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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