MyMedR

Leukaemia in adults

Bosco JJ

Family Practitioner, 1985;8:57-60.

Matched MeSH terms: Adult

A case of Sparganum prolifer infection

Marjoribanks RM, Le Sueur E

Trans R Soc Trop Med Hyg, 1924;18:70.

DOI: 10.1016/S0035-9203(24)90769-3

Matched MeSH terms: Adult; Young Adult

Nephrotic syndrome in adults

Cheong IKS

Family Practitioner, 1983;6:37-40.

Matched MeSH terms: Adult

Fulltext Renal angiomyolipoma--a case report

Yip FW, Lee SH

Singapore Med J, 1992 Dec;33(6):643-4.

PMID: 1488683

Renal angiomyolipoma is a benign tumour of the kidney which is often mistaken for a renal cell carcinoma resulting in an unnecessary nephrectomy. It can be diagnosed preoperatively and managed conservatively without surgery. Large symptomatic renal angiomyolipomas can often be treated by renal-sparing surgery. We report a case of a large renal angiomyolipoma diagnosed preoperatively and excised completely with preservation of the kidney.

Matched MeSH terms: Adult

Fulltext Three cases of sexual deviation seen at the University Hospital, Kuala Lumpur

Loke KH

Med J Malaysia, 1983 Dec;38(4):339-43.

PMID: 6599996

Sexually deviant behaviour is a fairly common phenomenon but because it is socially embarassing, a few cases come forward for consultation and treatment on a voluntary basis. Most cases are referred by the law courts. Two such cases, one of exhibitionism and the other offetishism, were referred to the University Hospital, Kuala Lumpur in 1982. Their development histories were elaborated. A third case of sexual sadism came voluntarily for help out defaulted after the initial session. A review on the current western concepts on sexual deviation is included in the text. It is concluded that although it is generally thought that neurological conditions give rise to deviant sexual behaviour, this assumption should not be arrived at hastily, as many cases of organic mental disorders do not exhibit deviant sexual
behaviour.

Matched MeSH terms: Adult

Fulltext Vogt-Koyanagi-Harada syndrome--a case report

Yusof Z, Pratap RC, Nor M, Reddy TN

Med J Malaysia, 1990 Mar;45(1):70-3.

PMID: 2152072

A 30 year old Malay male developed bilateral choroiditis followed by vitiligo, poliosis and canities. CT scan showed nodular thickening of the optic nerves. Characteristic abnormalities were seen in visual and brainstem auditory evoked potentials and fluorescein angiography. These findings were in keeping with the diagnosis of Vogt-Koyanagi-Harada syndrome. Treatment with dexamethasone resulted in complete recovery of vision and partial improvement in skin and hair lesions.

Matched MeSH terms: Adult

Pattern of heart disease in the adult population of Malaya

KHAIRA BS

Med J Malaya, 1961 Sep;16:81-9.

PMID: 14455502

Matched MeSH terms: Adult

Editorial: metagenome-assembled genomes in non-alcoholic fatty liver disease

Chan WK, Wong VW

Aliment Pharmacol Ther, 2021 03;53(6):755-756.

PMID: 33599321 DOI: 10.1111/apt.16280

Matched MeSH terms: Adult

Fulltext Chyluria and haematochyluria

Jansz R

Journal of the Straits Medical Association, 1894;5:58-64.

Matched MeSH terms: Adult

Fulltext A case of sclerosing keratitis profunda

Viswalingam A

Br J Ophthalmol, 1936 Aug;20(8):449-55.

PMID: 18169380

In October, 1931, A.L.J., an Anglo-Indian engineer, aged 59 years presented himself for examination on account of sore eyes and photophobia. The visual actuity was R.V. 6/12 with+0.75 sph.=6/6. L.V. 6/18 with+1 sph.=6/6. The pupils at that time were active to light and accommodation, the anterior chamber was slightly shallow and the tension not raised. The filtration atngle was " crowded."
Kuala Lumpur, Federated Malay States

Matched MeSH terms: Adult

An inquiry concerning the etiology of beri-beri

Fraser H, Stanton AT

Lancet, 1909;173(4459):451-5.

DOI: 10.1016/S0140-6736(01)80493-1

Matched MeSH terms: Adult

Asphyxia from defective ship-board ventilation

Brooke GE

Lancet, 1916;188:18.

DOI: 10.1016/S0140-6736(01)26402-2

Matched MeSH terms: Adult

Association between cardiovascular diseases and apical periodontitis: an umbrella review

Jakovljevic A, Duncan HF, Nagendrababu V, Jacimovic J, Milasin J, Dummer PMH

Int Endod J, 2020 Oct;53(10):1374-1386.

PMID: 32648971 DOI: 10.1111/iej.13364

BACKGROUND: The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive.

OBJECTIVE: To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults.

METHODS: The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of 'high', 'moderate', 'low' or 'critically low' quality.

RESULTS: Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as 'moderate' quality, whereas one review was graded as 'critically low' quality.

DISCUSSION: Only one systematic review included a meta-analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis.

CONCLUSIONS: From the limited 'moderate' to 'critically low' quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well-designed, longitudinal clinical studies with long-term follow-up are required.

Matched MeSH terms: Adult

Fulltext Rare presentation of idiopathic duodenoduodenal intussusception

Loo GH, Mohamad Abu Zeid WM, Lim SL, Ismail AM

Ann R Coll Surg Engl, 2017 Jul;99(6):e188-e190.

PMID: 28660832 DOI: 10.1308/rcsann.2017.0104

Enteroenteric intussusception is a condition in which the full-thickness bowel wall becomes telescoped into the lumen of distal bowel. Intussusception in adult occurs infrequently and varies from childhood intussusception, particularly in its presentation, aetiology and treatment. Duodenoduodenal intussusception is rare because the duodenum is fixed in the retroperitoneal position. It usually occurs secondary to tumour, lipoma, Brunner's gland hamartomatous polyp or adenoma. The diagnosis in adults is usually made at laparotomy, where presentation is with intestinal obstruction. In non-emergency presentation, it may be difficult to arrive at an accurate diagnosis as symptoms may be vague, self-limiting intermittent abdominal pain. Clinical examinations and investigations may not be conclusive and another working diagnosis such as irritable bowel syndrome would be made. We describe a case where a patient initially presented with symptoms mimicking pancreatitis but his symptoms persisted over the course of 2 weeks. When a laparotomy was performed, duodenoduodenal intussusception was discovered and confirmed with histopathology. In this case, a discernible leading point could not be identified.

Matched MeSH terms: Adult; Young Adult

Fulltext Prevalence of obesity among young adults in Africa - a meta-analysis

Rodo Mohamud Hassan, Regidor-111 Dioso

Malaysian Journal of Medical Research, 2017;1(3):1-6.

MyJurnal

Background: In Africa high prevalence of overweight and obesity was found in regions of East Africa (0.3%),
West Africa (0.7%), Central Africa (0.2%), South Africa (3.8%), and North Africa (12.5%).

Aims: This meta-analysis aimed to analyze the prevalence of obesity among young adults, aged 18-25 years
from five African countries.

Methods: The Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines were applied to
search published studies. of the 100 studies published as found in scientific databases from 2010 to 2017, only
five were selected. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
checklist was used to eliminate other studies.

Outcomes: A total of 22,320 obese young adults were analyzed to be prevalent. The obesity among adults in
SouthAfrica was found to be correlated with less physical activities. In Uganda, the prevalence of obesity is
683 which relates with their sedentary lifestyle and socio-demography. Among 371 young adults in Nigeria, the
prevalence of obesity was 5.1% among male and 10% among female related to diet and other consumptions.
Among 646 adults in Ghana, the prevalence of general obesity was observed to be related to genetics.

Conclusion: Prevalence of the male gender was 9,509 having a p=0.284 (at 95% C.I.±4,440.87845-
8,788.87845) with a mean score of 1,251, and a SD= 61,066. While the prevalence of obesity on females was
10,874 having a p= 0.00019, (at 95% C.I.±3,592.07-6,094.07) with a mean score of 2,174, and SD= 3,375.

Matched MeSH terms: Young Adult*

Validity and Reliability of the Wii Balance Board for Static Balance Assessment in Healthy Young Adults

Kaewkaen K, Uthama S, Ruengsirarak W, Puntumetakul R

Malays J Med Sci, 2019 Mar;26(2):114-121.

PMID: 31447614 DOI: 10.21315/mjms2019.26.2.12

Introduction: The Wii Balance Board (WBB) is a commonly used tool for balance assessment, however the inconsistency in the reported validity for the WBB when used for the assessment of healthy young adults needs to be clarified.

Aim: To investigate the concurrent validity and reliability of the WBB for balance assessment in healthy young adults.

Methods: Thirty-two young adults participated in this study. Their ability to balance was tested while standing on a WBB and a laboratory-grade force platform, under three conditions: feet together with eyes open, feet together with eyes closed and semi-tandem standing with eyes open. They had 10 min resting period between tests. The agreement between the WBB and the laboratory-grade force platform was investigated, and the reliability of the WBB was determined.

Results: A poor agreement between the WBB and the laboratory-grade force platform was found for all standing conditions [intraclass correlation coefficient (ICC) = 0.03 to 0.07]. A moderate to high reliability was found for the WBB for balance assessment in healthy young adults (ICC = 0.66 to 0.76).

Conclusion: The WBB was found to be a reliable tool for static balance assessment in healthy young adults. However, it had poor validity compared to the laboratory-grade force platform.

Matched MeSH terms: Adult; Young Adult

Fulltext Notes on two cases of paralysis

Hoad W

Journal of the Straits Medical Association, 1894;5:103-6.

Matched MeSH terms: Adult; Young Adult

Rectal Foreign Body: A Successful Removal at the Bedside and Detailing of a Stepwise Management

Gan DEY, Chan KH, Veerappan P, Sun KJ, Hayati F

Am J Case Rep, 2021 Jun 17;22:e930967.

PMID: 34135299 DOI: 10.12659/AJCR.930967

BACKGROUND A rectal foreign body (RFB) can be stigmatizing for patients and present a dilemma for the treating physician. Removal can be challenging owing to the variety of objects introduced. The goals of therapy are to safely remove the RFB and to minimize injury to the bowel. CASE REPORT A 22-year-old man was referred from a district hospital to our institution after being unable to remove a self-inflicted RFB after sexual gratification. He was hemodynamically stable with a soft and nontender abdomen. A mass was felt in the suprapubic region. Abdominal radiography revealed a well-defined radiolucent object in the pelvic region, which was consistent with a lubricant bottle. No sign of bowel obstruction or perforation was observed. The RFB was successfully retrieved by a combination of transrectal digital manipulation and directed gentle abdominal pressure, allowing for descent of the RFB and transanal traction at the bedside. Various approaches have been described for removal of a RFB, from simple bedside strategies to open surgery for complicated cases. Endoscopy and minimally invasive techniques have also demonstrated a role in formulating a tailored approach. CONCLUSIONS We describe a successful retrieval of an RFB at the bedside, avoiding unnecessary open surgery.

Matched MeSH terms: Adult; Young Adult

Fulltext An unusual presentation of adult onset Still's disease

Ghosal A, Pal RB, Das SK, Das T

Med J Malaysia, 2012 Oct;67(5):532-3.

PMID: 23770876

Adult onset still's disease usually presents with high grade intermittent fever, polyarthritis, salmon pink evanescent rash and hepatosplenomegaly. Pulmonary involvement in the form of pneumonitis, as a presenting feature is very rare. We report a case of a young lady who presented with fever, cough and respiratory distress. Chest X-ray revealed patchy infiltration in left upper lung zone. She was subsequently diagnosed as Adult onset Still's disease. There was no improvement in clinical condition despite five days of antibiotics. On trans-bronchial lung biopsy (TBLB) proved she had interstitial pneumonitis and responded dramatically to steroid treatment.

Matched MeSH terms: Adult; Still's Disease, Adult-Onset*

Small molecules enhance neurogenic differentiation of dental-derived adult stem cells

Heng BC, Jiang S, Yi B, Gong T, Lim LW, Zhang C

Arch Oral Biol, 2019 Jun;102:26-38.

PMID: 30954806 DOI: 10.1016/j.archoralbio.2019.03.024

OBJECTIVE: Dental-derived stem cells originate from the embryonic neural crest, and exhibit high neurogenic potential. This study aimed to investigate whether a cocktail of eight small molecules (Valproic acid, CHIR99021, Repsox, Forskolin, SP600125, GO6983, Y-27632 and Dorsomorphin) can enhance the in vitro neurogenic differentiation of dental pulp stem cells (DPSCs), stem cells from apical papilla (SCAPs) and gingival mesenchymal stem cells (GMSCs), as a preliminary step towards clinical applications.

MATERIALS AND METHODS: Neural induction was carried out with a small molecule cocktail based two-step culture protocol, over a total duration of 14 days. At the 8 and 14 day timepoints, the cells were analyzed for expression of neural markers with immunocytochemistry, qRT-PCR and Western Blot. The Fluo 4-AM calcium flux assay was also performed after a further 14 days of neural maturation.

RESULTS: More pronounced morphological changes characteristic of the neural lineage (i.e. neuritogenesis) were observed in all three cell types treated with small molecules, as compared to the untreated controls. This was corroborated by the immunocytochemistry, qRT-PCR and western blot data, which showed upregulated expression of several early and mature neural markers in all three cell types treated with small molecules, versus the corresponding untreated controls. Finally, the Fluo-4 AM calcium flux assay showed consistently higher calcium transient (F/Fo) peaks for the small molecule-treated versus untreated control groups.

CONCLUSIONS: Small molecules can enhance the neurogenic differentiation of DPSCs, SCAPs and GMSCs, which offer much potential for therapeutic applications.

Matched MeSH terms: Adult; Adult Stem Cells*

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