Affiliations 

  • 1 JSS Academy of Higher Education and Research, Mysuru, Karnataka 570 015, India
  • 2 Department of Studies in Biotechnology, Davangere University, Davangere, India
  • 3 ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Yelahanka, Bengaluru, Karnataka 560 064, India
  • 4 Department of Microbiology, Faculty of Medicine, Quest International University, Ipoh, Perak, Malaysia
  • 5 Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru, Karnataka 570 026, India
  • 6 Center for Biotechnology, Pravara Institute of Medical Sciences, Loni-413736, Rahata Taluk, Ahmednagar District, Maharashtra, India
  • 7 Malabar Cancer Centre, Department of Clinical Laboratory Services & Translational Research, Thalassery, Kannur 670103, India
Bioinformation, 2022;18(8):683-691.
PMID: 37323557 DOI: 10.6026/97320630018683

Abstract

There is a shred of evidence to suggest that Emblica officinalis Gaertn, the botanical name for amla seeds, has greater medicinal potential than amla fruit. We conducted this work to assess the anti-inflammatory, antibacterial, and antioxidant capacities of E. officinalis seed extracts. The bioactive components from the seeds were fractionated using chloroform, hexane, methanol, and diethyl ether, according to the polarity of the solvents. The total amount of phenolic and flavonoid was estimated. Both the reducing power and antioxidant capacities of the extracts were evaluated using the DPPH (1,1-diphenyl-2-picryl-hydrazyl) technique. 15-lipoxygenase (LOX) was inhibited by seed extracts at doses ranging from 5 to 25 micrograms. In silico docking was employed to assess the results. Some human pathogenic microorganisms were tested for their antibacterial activity using the agar disc diffusion method. Escherichia coli, Proteus vulgaris, and Klebsiella pneumonia were inhibited by a methanolic extract with an IC50 value of 58g, making it the most common organic solvent extract. Methanolic extracts also showed good antioxidant and antibacterial activity. Our investigation led us to discover that amla seeds have anti-inflammatory, antioxidant, and antibacterial effects.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.