• 1 Chitkara College of Pharmacy, Chitkara University, Punjab, India
  • 2 Chitkara College of Pharmacy, Chitkara University, Punjab, India.
  • 3 Department of Medicine Chemistry and Pharmacognosy, Qassim University, Buraidah, Kingdom of Saudi Arabia
  • 4 School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India
  • 5 Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
  • 6 Department of Pharmacology, Faculty of Medicine, AIMST University, Semeling, Kedah, Malaysia
  • 7 Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Nilgiris, Ooty, Tamilnadu, India
  • 8 Natural & Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman
  • 9 Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
  • 10 Department of Pharmacy, Faculty of Medicine of Pharmacy, University of Oradea, Oradea, Romania
PMID: 34997511 DOI: 10.1007/s11356-022-18531-5


Obesity is a multifaceted disease encompassing deposition of an unnecessary amount of fat which upsurges the possibility of other complications, viz., hypertension and certain type of cancers. Although obesity results from combination of genetic factors, improper diet and inadequate physical exercise also play a major role in its onset. The present study aims at exploring the anti-obesity activity of Crinum latifolia leaf extract in obese rats. The leaves were extracted using hydroalcoholic extraction which was later diluted with water and given to obese rats. The dosing was started from the 4th week (by oral administration of extract of Crinum latifolia (100 mg/kg and 200 mg/kg) and combination of Crinum latifolia leaf extract 200 mg/kg and orlistat 30 mg/kg) till the 10th week. Various angiogenic, antioxidant, biochemical, and inflammatory biomarkers were assessed at the end of the study. The obese symptoms were progressively reduced in treatment groups when compared to disease control groups. The angiogenic parameters and inflammatory parameters were consequently reduced in treatment groups. The oxidative parameters superoxide dismutase (SOD) and catalase were gradually increased, while levels of TBARS were reduced in treatment groups showing antioxidant nature of leaf hydroalcoholic extract. The Crinum latifolia leaf extract possesses anti-obesity properties and therefore can be used as a therapeutic option in the management of obesity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.