Affiliations 

  • 1 School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
  • 2 School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • 3 Medical Doctor, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
  • 4 Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  • 5 Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • 6 Tehran Medical Branch, Islamic Azad University, Tehran, Iran
  • 7 Department of Physical Chemistry, School of Chemistry, College of Sciences, University of Tehran, Tehran, Iran
  • 8 School of Medicine, Bam University of Medical Sciences, Bam, Iran
  • 9 Faculty of Medicine, National University of Malaysia, Bani, Malaysia
Chem Biol Drug Des, 2023 Oct;102(4):939-950.
PMID: 37402595 DOI: 10.1111/cbdd.14285

Abstract

The tumor microenvironment (TME) is well-defined target for understanding tumor progression and various cell types. Major elements of the tumor microenvironment are the followings: endothelial cells, fibroblasts, signaling molecules, extracellular matrix, and infiltrating immune cells. MicroRNAs (miRNAs) are a group of small noncoding RNAs with major functions in the gene expression regulation at post-transcriptional level that have also appeared to exerts key functions in the cancer initiation/progression in diverse biological processes and the tumor microenvironment. This study summarized various roles of miRNAs in the complex interactions between the tumor and normal cells in their microenvironment.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.