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Epigenetic regulation of temozolomide resistance in human cancers with an emphasis on brain tumors: Function of non-coding RNAs

Rezaee A 1 , Tehrany PM 2 , Tirabadi FJ 3 , Sanadgol N 4 , Karimi AS 5 , Ajdari A 6 Show all authors , Eydivandi S 7 , Etemad S 8 , Rajabi R 9 , Rahmanian P 10 , Khorrami R 11 , Nabavi N 12 , Aref AR 13 , Fan X 14 , Zou R 15 , Rashidi M 16 , Zandieh MA 17 , Hushmandi K 18

Affiliations 

  • 1 Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: rezaee.aryan@gmail.com
  • 2 Universiti Kebangsaan Malaysia Medical Centre, Malaysia. Electronic address: pmtehrany@gmail.com
  • 3 Faculty of Veterinary Medicine, Islamic Azad University, Science and Research Branch, Tehran, Iran. Electronic address: Farimahjafari1994@yahoo.com
  • 4 Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: Nsanadgol@gmail.com
  • 5 Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: Asalkarimi76@yahoo.com
  • 6 Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: Atraajdari1374@gmail.com
  • 7 Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: SepidehEydivandi@gmail.com
  • 8 Faculty of Veterinary Medicine, Islamic Azad University, Garmsar Branch, Semnan, Iran. Electronic address: Sarahetemad77@gmail.com
  • 9 Faculty of Veterinary Medicine, Islamic Azad University, Science and Research Branch, Tehran, Iran. Electronic address: rajabiromina74@gmail.com
  • 10 Faculty of Veterinary Medicine, Islamic Azad University, Science and Research Branch, Tehran, Iran. Electronic address: parham.rahmanian@gmail.com
  • 11 Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Electronic address: ramin.khorrami@ut.ac.ir
  • 12 Department of Urologic Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H3Z6, Canada. Electronic address: nnabavi@prostatecentre.com
  • 13 Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Translational Sciences, Xsphera Biosciences Inc. 6, Tide Street, Boston, MA 02210, USA. Electronic address: aref.smart@gmail.com
  • 14 Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong, China; The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China. Electronic address: fukui-hanson@hotmail.com
  • 15 Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong, China; The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China. Electronic address: zourj3@mail2.sysu.edu.cn
  • 16 Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: mrashidi@mazums.ac.ir
  • 17 Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Electronic address: m.aradzandieh@gmail.com
  • 18 Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Electronic address: houshmandi.kia7@ut.ac.ir
Biomed Pharmacother, 2023 Sep;165:115187.
PMID: 37499452 DOI: 10.1016/j.biopha.2023.115187

Abstract

Brain tumors, which are highly malignant, pose a significant threat to health and often result in substantial rates of mortality and morbidity worldwide. The brain cancer therapy has been challenging due to obstacles such as the BBB, which hinders effective delivery of therapeutic agents. Additionally, the emergence of drug resistance further complicates the management of brain tumors. TMZ is utilized in brain cancer removal, but resistance is a drawback. ncRNAs are implicated in various diseases, and their involvement in the cancer is particularly noteworthy. The focus of the current manuscript is to explore the involvement of ncRNAs in controlling drug resistance, specifically in the context of resistance to the chemotherapy drug TMZ. The review emphasizes the function of ncRNAs, particularly miRNAs, in modulating the growth and invasion of brain tumors, which significantly influences their response to TMZ treatment. Through their interactions with various molecular pathways, miRNAs are modulators of TMZ response. Similarly, lncRNAs also associate with molecular pathways and miRNAs, affecting the efficacy of TMZ chemotherapy. Given their functional properties, lncRNAs can either induce or suppress TMZ resistance in brain tumors. Furthermore, circRNAs, which are cancer controllers, regulate miRNAs by acting as sponges, thereby impacting the response to TMZ chemotherapy. The review explores the correlation between ncRNAs and TMZ chemotherapy, shedding light on the underlying molecular pathways involved in this process.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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