INTRODUCTION: Diabetes mellitus is a disease characterized by an increase in blood sugar levels due to abnormalities in the insulin hormone system. The number of people with this disease is expected to increase every year. Therefore, it is necessary to develop diabetes mellitus drugs that have effective performance in reducing blood glucose level. Coffee contain chlorogenic acid and caffeine. Chlorogenic acid play a role in increasing insulin sensitivity. However, the caffeine causes a decrease in glucose tolerance. The removal of caffeine or the decaffeination process is expected to improve the quality of coffee as an anti-diabetic drug. The aim of this study was to investigate the effectiveness of decaffeinated coffee extract in reducing blood sugar.
MATERIALS AND METHODS: Green or roasted coffee extract was decaffeinated using activated charcoal. Decaffeinated coffee extract with the lowest caffeine and the highest chlorogenic acid based on HPLC measurement was used for antidiabetic test. The anti-diabetic test was conducted with 52 DM type 2 patient selected by purposive sample. The test were divided into two groups: intervention (26 respondents) and control group (26 respondents). The data were analysed by Paired and Independent t test.
RESULTS: Decaffeinated green coffee extract is very suitable for use as a drug to lower blood sugar in DM type 2 patients than decaffeinated roasted coffee extract because of higher in chlorogenic acid and lower in caffeine (Figure 2). Treatment by decaffeinated green coffee extract for 3 weeks showed a significant decrease in average fasting blood glucose level from 144.7 g/dl to 92.23 g/dl. All statistical tests showed a p value = 0.001 (below the significant value), this value proves the success of reducing blood glucose by decaffeinated green coffee extract.
CONCLUSION: The decaffeinated green coffee extract decreases fasting blood sugar significantly.
* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.