MATERIALS AND METHODS: Green or roasted coffee extract was decaffeinated using activated charcoal. Decaffeinated coffee extract with the lowest caffeine and the highest chlorogenic acid based on HPLC measurement was used for antidiabetic test. The anti-diabetic test was conducted with 52 DM type 2 patient selected by purposive sample. The test were divided into two groups: intervention (26 respondents) and control group (26 respondents). The data were analysed by Paired and Independent t test.

RESULTS: Decaffeinated green coffee extract is very suitable for use as a drug to lower blood sugar in DM type 2 patients than decaffeinated roasted coffee extract because of higher in chlorogenic acid and lower in caffeine (Figure 2). Treatment by decaffeinated green coffee extract for 3 weeks showed a significant decrease in average fasting blood glucose level from 144.7 g/dl to 92.23 g/dl. All statistical tests showed a p value = 0.001 (below the significant value), this value proves the success of reducing blood glucose by decaffeinated green coffee extract.