Affiliations 

  • 1 Department of Biomedical Sciences, Advanced Medical & Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia
  • 2 Department of Physiology, Xuzhou Medical University, Xuzhou, People's Republic of China
  • 3 Department of Medical Laboratory Sciences, University of Health & Allied Sciences, PMB 31, Ho, Ghana
Future Oncol, 2023 Nov;19(35):2369-2382.
PMID: 37970643 DOI: 10.2217/fon-2023-0426

Abstract

Colorectal cancer (CRC) is a significant contributor to cancer mortality worldwide, and the presence of cancer stem cells (CSC) represents a major challenge for achieving effective treatment. miRNAs have emerged as critical regulators of gene expression, and recent studies have highlighted their role in regulating stemness and therapeutic resistance in CRC stem cells. This review highlights the mechanisms of CSC development, therapy resistance and the potential of miRNAs as therapeutic targets for CRC. It emphasizes the promise of miRNAs as a novel approach to CRC treatment and calls for further research to explore effective miRNA-based therapies and strategies for delivering miRNAs to CSCs in vivo.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.