Affiliations 

  • 1 State Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet, Chennai, Tamil Nadu, India
  • 2 Department of Biotechnology, Infection and Inflammation, Central University of Tamil Nadu, Thiruvarur, India
  • 3 Laboratory Centre, Xiamen University Malaysia, Sepang, Selangor, Malaysia
  • 4 National Tuberculosis Elimination Programme, Chennai, Tamil Nadu, India
  • 5 Department of Life Sciences, Blood and Vascular Biology, Central University of Tamil Nadu, Thiruvarur, India
  • 6 Department of Epidemiology and Public Health, Central University of Tamil Nadu, Thiruvarur, India
  • 7 Pre-clinical Department, Royal College of Medicine, Universiti Kuala Lumpur, Ipoh, Malaysia
  • 8 Department of Microbiology, The Government Theni Medical College and Hospital, Theni, India
  • 9 Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
  • 10 Seattle Children's Research Institute, Seattle, WA, United States of America
  • 11 Department of Microbiology, Saveetha Institute of Medical and Technical Sciences (SIMATS), Centre for Infectious Diseases, Velappanchavadi, Chennai, India
  • 12 Department of Pathology and Laboratory Medicine, Division of Microbiology and Immunology, Emory University School of Medicine, Emory National Primate Research Center, Emory Vaccine Center, Atlanta, GA, United States of America
  • 13 Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
  • 14 Department of Biomedicine and Clinical Sciences, Linkoping University, Linköping, Sweden
PLOS Glob Public Health, 2023;3(11):e0002327.
PMID: 37992019 DOI: 10.1371/journal.pgph.0002327

Abstract

Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. The plasma cytokines were measured using a commercial Bio-Plex Pro Human Cytokine 17-plex assay. Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. Our study suggests that CXCL-8 and MCP-1 could serve as the surrogate biomarkers of LTBI, particularly in resource-limited settings. Further laboratory investigations are warranted before extrapolating CXCL8 and MCP-1 for their usefulness as surrogate biomarkers of LTBI in resource-limited settings.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.