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Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection

Selvavinayagam ST 1 , Aswathy B 2 , Yong YK 3 , Frederick A 4 , Murali L 4 , Kalaivani V 1 Show all authors , Jith KS 2 , Rajeshkumar M 1 , Anusree A 5 , Kannan M 5 , Gopalan N 6 , Vignesh R 7 , Murugesan A 8 , Tan HY 3 , Zhang Y 3 , Chandramathi S 9 , Sivasankaran MP 10 , Govindaraj S 11 , Byrareddy SN 12 , Velu V 11 , Larsson M 13 , Shankar EM 2 , Raju S 1

Affiliations 

  • 1 State Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet 600 018, Chennai, Tamil Nadu, India
  • 2 Infection and Inflammation, Department of Biotechnology, Central University of Tamil Nadu, Thiruvarur 610 005, India
  • 3 Laboratory Centre, Xiamen University Malaysia, 43 900 Sepang, Selangor, Malaysia
  • 4 National Tuberculosis Elimination Programme, Chennai, Tamil Nadu, India
  • 5 Blood and Vascular Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610 005, India
  • 6 Department of Epidemiology and Public Health, Central University of Tamil Nadu, Thiruvarur 610 005, India
  • 7 Pre-clinical Department, Royal College of Medicine, Universiti Kuala Lumpur, Ipoh, Malaysia
  • 8 Department of Microbiology, The Government Theni Medical College and Hospital, Theni, India
  • 9 Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
  • 10 Seattle Children's Research Institute, Seattle, WA, USA
  • 11 Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory Vaccine Center, Atlanta, GA, 30329, USA
  • 12 Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68131, USA
  • 13 Department of Biomedicine and Clinical Sciences, Linkoping University, 58 185 Linköping, Sweden
medRxiv, 2023 Aug 09.
PMID: 37609153 DOI: 10.1101/2023.08.07.23293767

Abstract

BACKGROUND: Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy.

METHODS: We investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. We also measured the plasma cytokines using a commercial Bio-Plex Pro Human Cytokine 17-plex assay.

RESULTS: Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold.

CONCLUSIONS: We postulated that CXCL8 and MCP-1 could be the surrogate biomarkers of LTBI, especially in resource-limited settings.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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