Affiliations 

  • 1 Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, Malaysia
  • 2 Faculty of Science and Technology, Universiti Sains Islam Malaysia (USIM), Bandar Baharu Nilai, 71800, Nilai, Negeri Sembilan, Malaysia
  • 3 Kulim Hi-Tech Pte Ltd, No.1, Jalan Bukit Hijau 26/24, Section 26, 40400, Shah Alam, Selangor, Malaysia
Heliyon, 2023 Dec;9(12):e22926.
PMID: 38125452 DOI: 10.1016/j.heliyon.2023.e22926

Abstract

Uric acid is a waste product of the human body where high levels of it or hyperuricemia can lead to gout, kidney disease and other health issues. In this paper, Finite Difference Time Doman (FDTD) simulation method was used to develop a plasmonic optical sensor to detect uric acid with molarity ranging from 0 to 3.0 mM. A hybrid layer of gold-zinc oxide (Au-ZnO) was used in this Kretschmann-based Surface Plasmon Resonance (K-SPR) technique with angular interrogation at 670 nm and 785 nm visible optical wavelengths. The purpose of this study is to observe the ability of the hybrid material as a sensing performance enhancer for differentiating between healthy and unhealthy uric acid levels based on the refractive index values from previous study. Upon exposure to 670 nm wavelength, the average sensitivity of this sensor was found to be 0.028°/mM with a linearity of 98.67 % and Q-factor value of 0.0053 mM-1. While at 785 nm, the average sensitivity is equal to 0.0193°/mM with slightly lower linearity at 94.46 % and Q-factor value of 0.0076 mM-1. The results have proven the ability of hybrid material Au-ZnO as a sensing performance enhancer for detecting uric acid when compared with bare Au and can be further explored in experimental work.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.