Comparable down-regulation of TYR, TYRP1 and TYRP2 genes and inhibition of melanogenesis by tyrostat, tocotrienol-rich fraction and tocopherol in human skin melanocytes improves skin pigmentation

Makpol S 1 , Jam FA 1 , Rahim NA 1 , Khor SC 1 , Ismail Z 2 , Yusof YA 1 Show all authors , Wan Ngah WZ 1

Affiliations 

  • 1 Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
  • 2 Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia, and 2R&D Plantation and Agri-Business Division, Sime Darby Research Sdn Bhd, 42960 Carey Island, Selangor, Malaysia
Clin Ter, 2014;165(1):e39-45.
PMID: 24589959

Abstract

Antioxidant has been recognized to inhibit UV-induced melanogenesis. This study aimed to elucidate the molecular mechanism of tyrostat, tocopherol and tocotrienol-rich fraction in inhibiting melanogenesis in human skin melanocytes.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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