Infective endocarditis is a potentially life-threatening condition caused by a bacterial infection of the heart valves. The incidence of splenic abscess associated with infective endocarditis varies between 1-10% of cases, and its presence may indicate a severe form of the disease. We present a 24-year-old man diagnosed with infective endocarditis who was found to have a splenic abscess upon further evaluation. The patient was initially managed conservatively with targeted antibiotics, but after unsuccessful percutaneous drainage, a splenectomy was performed. The patient underwent mitral valve replacement surgery and made a good recovery. The patient's case highlights the importance of considering a secondary abscess in the management of infective endocarditis. This complication can easily be missed and cause significant morbidity. This case underscores the importance of early diagnosis and effective collaboration between various healthcare professionals to achieve the best possible outcome for patients with infective endocarditis and its associated complications.
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