Affiliations 

  • 1 Department of Chemistry, School of Basic Sciences, Jaipur National University, Jaipur, 302017 (Rajasthan) India
  • 2 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
  • 3 Department of Environmental, Biological and Pharmaceutical Science and Technology (DISTABiF), University of Campania 'Luigi Vanvitelli' Via Vivaldi 43, 81100 Caserta, Italy
  • 4 Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India
  • 5 Department of Chemistry, Millat College (A constituent colle ge of Lalit Narayan Mithila University), Darbhanga, Bihar, India
  • 6 Division of Chemistry and Biotechnology, Dongguk University, 123, Dongdaero, Gyeongju-si 780714, Republic of Korea
  • 7 Environmental Technology Division, School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia
Heliyon, 2024 Mar 30;10(6):e27787.
PMID: 38496878 DOI: 10.1016/j.heliyon.2024.e27787

Abstract

The current study report a convenient, simple, and low cost approach for the biogenic synthesis of CuO/Fe3O4 nanocomposites (NCs) from pumpkin seeds extract and their vitro cytotoxicity. The characterization of finally obtained CuO/Fe3O4 nanocomposites (NCs) performed using UV-Visible, FT-IR, XRD, XPS, GC-MS, SEM-EDX and TEM analysis. The formation and elemental analysis were determined using the energy-dispersive X-ray (EDX) microanalysis technique. The formation of rod-like monoclinic and spherical, having size range 5 nm-20 nm confirmed by scanning electron microscope (SEM) and transmission electron microscopy (TEM) respectively. Finally, the MTT assay of the synthesized composites was evaluated for toxicity against cancerous cell lines HCT-116 (Colon cancer cell) and A549 (human lung adenocarcinoma cell). The synthesized composite material showed moderate (IC50 = 199 μg/mL) to low (IC50 = 445 μg/mL) activity against HCT-116 and A549 cell lines, respectively.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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