Affiliations 

  • 1 School of Life and Basic Sciences, Jaipur National University, Jaipur, Rajasthan 302017, India
  • 2 Environmental Technology Division, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia
  • 3 Department of Physics, Faculty of Sciences, University 20 Août 1955, Skikda, Algeria
  • 4 Department of Environmental Science, Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat 391760, India; Environmental and Atmospheric Sciences Research Group, Scientific Research Center, Al-Ayen University, Nasiriyah, Thi-Qar, Iraq. Electronic address: envirokrishna@gmail.com
  • 5 Department of Environmental Science, Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat 391760, India
  • 6 Department of Electrical Engineering, College of Engineering, King Khalid University, Abha, Saudi Arabia
  • 7 CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
  • 8 Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin AbdulAziz University, Al-Kharj, Riyadh 11942, Saudi Arabia
  • 9 Department of Chemistry, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India
  • 10 Department of Mechanical Engineering King Khalid University, Saudi Arabia
  • 11 Department of Chemistry, University of Ha'il, Ha'il 81441, Saudi Arabia
  • 12 Department of Physics, College of Science, King Faisal University, Al Ahsa 31982, Saudi Arabia. Electronic address: wmir@kfu.edu.sa
Toxicology, 2024 Nov 06;509:153985.
PMID: 39510373 DOI: 10.1016/j.tox.2024.153985

Abstract

Nanotechnology arising in wide-ranging areas, covers extensively different ranges of approaches attained from fields such as biology, chemistry, physics, and medicine engineering. Nanoparticles are a necessary part of nanotechnology effectually applied in the cure of a number of diseases. Nanoparticles have gained significant importance due to their unique properties, which differ from their bulk counterparts. These distinct properties of nanoparticles are primarily influenced by their morphology, size, and size distribution. At the nanoscale, nanoparticles exhibit behaviours that can enhance therapeutic efficacy and reduce drug toxicity. Their small size and large surface area make them promising candidates for applications such as targeted drug delivery, where they can improve treatment outcomes while minimizing adverse effects. The harmful effects of nanoparticles on the environment were critically investigated to obtain appropriate results and reduce the risk by incorporating the materials. Nanoparticles tend to penetrate the human body, clear the biological barriers to reach sensitive organs and are easily incorporated into human tissue, as well as dispersing to the hepatic tissues, heart tissues, encephalum, and GI tract. This study aims to examine a wide variety of nanoparticles, focusing on their manufacturing methods, functional characteristics, and interactions within biological systems. Particular attention will be directed towards assessing the toxicity of nanoparticles in different organs and physiological systems, yielding a thorough comprehension of their potential health hazards and the processes that drive nanoparticle-induced toxicity. This analysis will also emphasize recent developments in nanoparticle applications and safety assessment methodologies.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.