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Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey

Yoshida A 1 , Li Y 2 , Maroufy V 2 , Kuwana M 1 , Sazliyana Shaharir S 3 , Makol A 4 Show all authors , Sen P 5 , Lilleker JB 6 , Agarwal V 7 , Kadam E 8 , Akawatcharangura Goo P 9 , Day J 10 , Milchert M 11 , Chen YM 12 , Dey D 13 , Velikova T 14 , Saha S 15 , Edgar Gracia-Ramos A 16 , Parodis I 17 , Nikiphorou E 18 , Tan AL 19 , Nune A 20 , Cavagna L 21 , Toro Gutiérrez CE 22 , Caballero-Uribe CV 23 , Saavedra MA 24 , Shinjo SK 25 , Ziade N 26 , El Kibbi L 27 , Knitza J 28 , Distler O 29 , Chinoy H 30 , Agarwal V 31 , Aggarwal R 32 , Gupta L 30 , COVAD Study Group

Affiliations 

  • 1 Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan
  • 2 Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA
  • 3 UKM Medical Centre, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Cheras, Malaysia
  • 4 Division of Rheumatology, Mayo Clinic, Rochester, MN, USA
  • 5 Maulana Azad Medical College, New Delhi, Delhi, India
  • 6 Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
  • 7 Mahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India
  • 8 Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India
  • 9 Department of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand
  • 10 Department of Rheumatology, Royal Melbourne Hospital, Parkville, VIC, Australia
  • 11 Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin, Szczecin, Poland
  • 12 Division of Allergy, Immunology and Rheumatology, Department of Medical Research, Taichung Veterans General Hospital, Taiwan
  • 13 Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences, Accra, Ghana
  • 14 Medical Faculty, Sofia University St Kliment Ohridski, Sofia, Bulgaria
  • 15 Mymensingh Medical College, Mymensingh, Bangladesh
  • 16 Department of Internal Medicine, General Hospital, National Medical Center "La Raza", Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • 17 Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
  • 18 Centre for Rheumatic Diseases, King's College London, London, UK
  • 19 NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK
  • 20 Southport and Ormskirk Hospital NHS Trust, Southport, UK
  • 21 Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Università degli studi di Pavia, Pavia, Lombardy, Italy
  • 22 Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Colombia
  • 23 Department of Medicine, Hospital Universidad del Norte, Barranquilla, Atlantico, Colombia
  • 24 Departamento de Reumatología Hospital de Especialidades Dr Antonio Fraga Mouret, Centro Médico Nacional La Raza, IMSS, Mexico City, Mexico
  • 25 Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil
  • 26 Rheumatology Department, Saint-Joseph University, Beirut, Lebanon
  • 27 Department of Rheumatology, Specialised Medical Center Hospital, Alfaisal University, Riyadh, Saudi Arabia
  • 28 Medizinische Klinik 3 - Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland
  • 29 Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
  • 30 Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, University of Manchester, Manchester, UK
  • 31 Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
  • 32 Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Rheumatol Adv Pract, 2024;8(2):rkae028.
PMID: 38524696 DOI: 10.1093/rap/rkae028

Abstract

OBJECTIVES: To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database.

METHODS: Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed. Primary outcomes were PROMIS Global Physical Health (GPH) and Global Mental Health (GMH) scores. Factors affecting GPH and GMH scores in IIMs were identified using multivariable regression analysis.

RESULTS: We analysed responses from 1582 IIM, 4700 non-IIM AIRD and 545 nrAID patients and 3675 controls gathered through 23 May 2022. The median GPH scores were the lowest in IIM and non-IIM AIRD patients {13 [interquartile range (IQR) 10-15] IIMs vs 13 [11-15] non-IIM AIRDs vs 15 [13-17] nrAIDs vs 17 [15-18] controls, P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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