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The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset

Fornaro M 1 , Venerito V 1 , Pellico MR 2 , Iannone F 1 , Joshi M 3 , Chen YM 4 Show all authors , Tan AL 5 , Saha S 6 , Chatterjee T 7 , Agarwal V 8 , Shinjo SK 9 , Hoff LS 10 , Kadam E 11 , Ziade N 12 , Velikova T 13 , Hasan ATMT 14 , Shumnalieva R 15 , Milchert M 16 , Tan CL 17 , Gracia-Ramos AE 18 , Cavagna L 19 , Vaidya B 20 , Kuwana M 21 , Shaharir SS 22 , Knitza J 23 , Makol A 24 , Tehozol EAZ 25 , Serrano JR 26 , Halabi H 27 , Dey D 28 , Toro-Gutiérrez CE 29 , Goo PA 30 , Caballero-Uribe CV 31 , Distler O 32 , Katchamart W 33 , Day J 34 , Parodis I 35 , Nikiphorou E 36 , Chinoy H 37 , Agarwal V 38 , Gupta L 37 , CoVAD Study Group

Affiliations 

  • 1 Department of Precision and Regenerative Medicine and Ionian Area, Rheumatology Unit, University of Bari, Bari, Italy
  • 2 Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milan, Italy
  • 3 Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India
  • 4 Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
  • 5 NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK
  • 6 Mymensingh Medical College, Mymensingh, Bangladesh
  • 7 Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA
  • 8 Mahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India
  • 9 Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
  • 10 School of Medicine, Universidade Potiguar (UnP), Brazil
  • 11 Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India
  • 12 Rheumatology Department, Saint-Joseph University, Beirut, Lebanon
  • 13 Medical Faculty, Sofia University St Kliment Ohridski, Sofia, Bulgaria
  • 14 Department of Rheumatology, Green Life Medical College, Dhaka, Bangladesh
  • 15 Department of Rheumatology, Clinic of Rheumatology, University Hospital 'St Ivan Rilski', Medical University, Sofia, Bulgaria
  • 16 Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin, Szczecin, Poland
  • 17 Rheumatology Unit, Department of Internal Medicine, Hospital Sultanah Bahiyah, Alor Setar, Malaysia
  • 18 Department of Internal Medicine, General Hospital, National Medical Center "La Raza", Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • 19 Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Università degli studi di Pavia, Pavia, Lombardy, Italy
  • 20 National Center for Rheumatic Diseases (NCRD), Ratopul, Kathmandu, Nepal
  • 21 Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan
  • 22 Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia
  • 23 Medizinische Klinik 3-Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
  • 24 Division of Rheumatology, Mayo Clinic, Rochester, MN, USA
  • 25 Rheumatology, Medical Care & Research, Centro Medico Pensiones Hospital, Instituto Mexicano del Seguro Social Delegación Yucatán, Yucatán, Mexico
  • 26 Rheumatologist and Clinical Investigator, Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
  • 27 Department of Internal Medicine, Section of rheumatology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia
  • 28 Rheumatology Unit, Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences, Korle-Bu, Accra, Ghana
  • 29 General Director, Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Colombia
  • 30 Department of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand
  • 31 Department of Medicine, Hospital Universidad del Norte, Barranquilla, Atlantico, Colombia
  • 32 Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
  • 33 Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • 34 Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
  • 35 Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
  • 36 Centre for Rheumatic Diseases, King's College London, London, UK
  • 37 Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre The University of Manchester, Manchester, UK
  • 38 Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Rheumatology (Oxford), 2025 Apr 01;64(4):2133-2142.
PMID: 39324556 DOI: 10.1093/rheumatology/keae520

Abstract

OBJECTIVE: The presence of comorbidities can substantially affect patients' quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited.

METHODS: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping.

RESULTS: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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