Affiliations 

  • 1 Department of Oral and Maxillofacial Surgery, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamil Nadu, India
  • 2 Department of Pedodontics and Preventive Dentistry, KIMS Dental College and Hospital, Amalapuram, Andhra Pradesh, India
  • 3 KIMS Dental College and Hospital, Amalapuram, Andhra Pradesh, India
  • 4 Department of Public Health Dentistry, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India
  • 5 Faculty of Dentistry, MAHSA University, Malaysia
  • 6 Department of Pediatric Dentistry, Faculty of Dentistry, MAHSA University, Selangor, Malaysia
J Pharm Bioallied Sci, 2024 Feb;16(Suppl 1):S227-S229.
PMID: 38595345 DOI: 10.4103/jpbs.jpbs_469_23

Abstract

AIM: The present study was conducted for assessing variability in calretinin expression among odontogenic cysts as well as tumor cases.

MATERIALS AND METHODS: Fifteen cases were included in the present research consisting of cases like - dentigerous cyst, odontogenic keratocyst, apical radicular cyst along with tumors like ameloblastoma, ameloblastic carcinoma, adenomatoid odontogenic tumor. Calretinin antibody was used for immunohistochemical staining. The amount of expression of this calretinin was statistically analyzed with the help of Chi-square test where P < 0.05 was considered noteworthy statistically.

RESULTS: Most cases of ameloblastomas were highly positive for calretinin expression as compared to other cysts and tumors. Therefore, the correlation of this variation of expression of calretinin was statistically noteworthy (P = 0.00).

CONCLUSION: In this study, we concluded that for ameloblastomas, calretinin can be a specific marker immunohistochemically and can help in identifying the amount of aggressive spread of various odontogenic tumors.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.