Affiliations 

  • 1 Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Perak, Malaysia
  • 2 Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA, Bandar Puncak Alam, Selangor, Malaysia
  • 3 Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Pahang, Malaysia
Nat Prod Res, 2024 May 20.
PMID: 38766974 DOI: 10.1080/14786419.2024.2353914

Abstract

This study was designed to investigate the chemical composition of the essential oil of Syzygium variolosum (King) Chantar. & J.Parn. and their cytotoxicity, acetylcholinesterase, antityrosinase, and anti-inflammatory activities. In total, 32 chemical components were identified in the essential oil, which made up 98.9%. The essential oil is mainly composed of β-elemene (20.2%), bicyclogermacrene (13.5%), viridiflorol (11.1%), globulol (8.6%), and selin-11-en-4α-ol (5.3%). Acetylcholinesterase, antityrosinase, and anti-inflammatory activities were evaluated with the Ellman method, mushroom tyrosinase, and lipoxygenase enzymes, respectively, while cytotoxicity was assessed using an MTT assay. The results showed that essential oil gave significant percentage inhibition (I%: acetylcholinesterase 35.2%, antityrosinase 42.5%, lipoxygenase 48.6%). Furthermore, the essential oil exhibited cytotoxicity against three cancer cell lines, HepG2, MCF7, and A549, with IC50 values ranging from 90.2 to 95.2 μg/mL. The current study highlights the potential of the use of essential oils as an alternative to the development of pharmaceutical antichemopreventives or cosmetics.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.