Affiliations 

  • 1 Breast Unit, Champalimaud Clinical Centre/Champalimaud Foundation, and ABC Global Alliance, Lisbon, Portugal. Electronic address: fatimacardoso@fundacaochampalimaud.pt
  • 2 Hadassah University Hospital - Sharett Institute of Oncology, Jerusalem, Israel
  • 3 Mamma Mia, Kronberg, Germany
  • 4 Breast Unit, Champalimaud Clinical Centre/Champalimaud Foundation, Lisbon, Portugal
  • 5 BC Cancer Agency, Department of Medical Oncology, Vancouver, Canada
  • 6 Cancer Center, Clinique de Genolier, Genolier, Switzerland
  • 7 Tata Memorial Centre, HBNI, Mumbai, India
  • 8 Latin American Cooperative Oncology Group (LACOG), Grupo Oncoclínicas, Porto Alegre, Brazil
  • 9 Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden
  • 10 Europa Donna - the European Breast Cancer Coalition, Norrkoping, Sweden
  • 11 Department of Oncology, Hospital of Prato - Azienda USL Toscana Centro Prato, Italy and European Society of Breast Cancer Specialists (EUSOMA), Italy
  • 12 Breast Unit, Champalimaud Clinical Centre/Champalimaud Foundation and Lisbon University, Faculty of Medicine, Lisbon, Portugal
  • 13 UNC Lineberger Comprehensive Cancer Center, Chapel Hill, USA
  • 14 Health Services Research, Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, USA and American Society of Clinical Oncology (ASCO), Houston, USA
  • 15 Project PINKBLUE, Abuja, Nigeria
  • 16 International Breast Cancer Center (IBCC), Madrid and Barcelona, Spain
  • 17 European Institute of Oncology, IRCCS, Milano, Italy; Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy
  • 18 National Cancer Center Singapore, Singapore, Singapore
  • 19 NK Basile Cancer Institute, American University of Beirut Medical Center, Beirut, Lebanon
  • 20 Hôpital Riviera-Chablais, Vaud-Valais Rennaz, Switzerland and European School of Oncology (ESO), United Kingdom
  • 21 Brighton & Sussex Medical School, University of Sussex, Brighton, United Kingdom
  • 22 Department of Medical Oncology, Peter MacCallum Cancer Centre, Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia
  • 23 CTIC, Cancer Treatment and Research Center, Bogotá, Colombia
  • 24 Macquarie University, Sydney, Australia
  • 25 Department of Medical Oncology, Cancer Est APHP Tenon, University Paris VI, Nice/St Paul Guidelines, Paris, France
  • 26 Northwestern Medicine, Illinois, USA and National Comprehensive Cancer Network (NCCN), USA
  • 27 Brustkrebs Deutschland e.V., Munich, Germany
  • 28 Breast Centre, University of Munich, Munich and Arbeitsgemeinschaft Gynäkologische Onkologie, Kommission Mamma (AGO Guidelines), Germany
  • 29 Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
  • 30 Breast Cancer Welfare Association, Petaling Jaya, Malaysia
  • 31 NHMRC Clinical Trials Centre, Sydney Medical School, Sydney, Australia
  • 32 Asan Medical Centre, Department of Oncology, Seoul, South Korea
  • 33 Lilavati Hospital and Research Centre, Bombay Hospital Institute of Medical Sciences, Asian Cancer Institute, Mumbai, India
  • 34 Te Whatu Ora Waikato, Midland Regional Cancer Centre, NZ ABC Guidelines, Hamilton, New Zealand
  • 35 Department of Radiology, Institut Roi Albert II and Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium
  • 36 Inflammatory Breast Cancer Research Foundation, West Lafayette, USA
  • 37 MBC US Alliance and Metastatic Breast Cancer Network US, Inverness, USA
  • 38 University Medical Center Hamburg-Eppendorf, Hamburg and Arbeitsgemeinschaft Gynäkologische Onkologie, Kommission Mamma (AGO Guidelines), Germany
  • 39 Breast Cancer Now, London, United Kingdom
  • 40 Department of Medical Oncology, National Institute of Neoplastic Diseases, Lima, ABC Latin America Guidelines, Peru
  • 41 Department of Oncology, Aarhus University Hospital, Aarhus, European Society for Radiotherapy and Oncology (ESTRO), Denmark
  • 42 Breast Oncology Centre, Cancer Institute Hospital, Tokyo, Japan
  • 43 Hôpital Riviera-Chablais, Vaud-Valais Rennaz, Switzerland
  • 44 Dana-Farber Cancer Institute, Department of Medical Oncology and Division of Breast Oncology, Boston, USA and American Society of Clinical Oncology (ASCO), USA
  • 45 Centre Jean Perrin, Université Clermont Auvergne, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, F-63000, Clermont Ferrand, Nice/St Paul Guidelines, France
  • 46 Hospital Clínic of Barcelona, University of Barcelona, Barcelona, Spain
  • 47 Breast Oncology and Clinical Trials Education, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, USA
  • 48 Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland
  • 49 Division of Oncology, Stanford School of Medicine, Stanford, USA
  • 50 Georgetown University Lombardi Comprehensive Cancer Center and MedStar Health, Washington DC, USA
  • 51 Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale) and Arbeitsgemeinschaft Gynäkologische Onkologie, Kommission Mamma (AGO Guidelines), Germany
  • 52 Belong.Life, New York, USA
  • 53 University of Botswana, Gaborone, Botswana and CHU UCL Namur Hospital, UCLouvain, Belgium
  • 54 The Royal Marsden NHS Foundation Trust, University of Southampton, United Kingdom and European Oncology Nursing Society (EONS), United Kingdom
  • 55 Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  • 56 European School of Oncology, Milan, Italy and Bellinzona, Switzerland
  • 57 Breast Cancer Programs, Memorial Sloan-Kettering Cancer Centre, New York, USA
  • 58 Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA
Breast, 2024 Aug;76:103756.
PMID: 38896983 DOI: 10.1016/j.breast.2024.103756

Abstract

This manuscript describes the Advanced Breast Cancer (ABC) international consensus guidelines updated at the last two ABC international consensus conferences (ABC 6 in 2021, virtual, and ABC 7 in 2023, in Lisbon, Portugal), organized by the ABC Global Alliance. It provides the main recommendations on how to best manage patients with advanced breast cancer (inoperable locally advanced or metastatic), of all breast cancer subtypes, as well as palliative and supportive care. These guidelines are based on available evidence or on expert opinion when a higher level of evidence is lacking. Each guideline is accompanied by the level of evidence (LoE), grade of recommendation (GoR) and percentage of consensus reached at the consensus conferences. Updated diagnostic and treatment algorithms are also provided. The guidelines represent the best management options for patients living with ABC globally, assuming accessibility to all available therapies. Their adaptation (i.e. resource-stratified guidelines) is often needed in settings where access to care is limited.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.