Affiliations 

  • 1 Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran
  • 2 Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania & Department of Hematology, Centre of Hematology and Bone Marrow Transplantation Fundeni Clinical Institute Bucharest Romania
  • 3 Department of Nutrition and Food Hygiene, Nutrition Health Research Center Hamadan University of Medical Sciences Hamadan Iran
  • 4 UKM Medical Molecular Biology Institute Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia
  • 5 Department of Pharmacy Practice, Faculty of Pharmacy University of Tabuk Tabuk Saudi Arabia
  • 6 University of Normandie Caen France
  • 7 School of Medicine Federal University of Uberlandia (UFU) Uberlandia Brazil
Food Sci Nutr, 2024 Jul;12(7):4581-4593.
PMID: 39055215 DOI: 10.1002/fsn3.4146

Abstract

Hepcidin has a crucial role in iron homeostasis upon inflammatory conditions such as inflammatory bowel disease (IBD). Thus, we conducted a systematic review and meta-analysis to determine the overall association between serum hepcidin concentrations and IBD. Based on the preferred reporting items for systematic review and meta-analysis (PRISMA) protocols, an electronic literature search was conducted on PubMed/MEDLINE, Scopus, and Web of Science until June 2020. Studies were deemed eligible for inclusion if they met the following criteria: (1) diagnosis of IBD, (2) observational design, and (3) measured serum hepcidin and prohepcidin concentrations in IBD patients and control group. Overall, 10 studies including 1184 participants were evaluated. Random-effects meta-analysis revealed that subjects with IBD had 7.22 ng/mL (95% CI: 2.10, 12.34; p = .006) higher serum hepcidin concentrations compared to control groups. A nonsignificantly lower serum prohepcidin concentration (0.522 ng/mL, 95% CI: -1.983 to 0.939; p = .484) was found for IBD patients compared to healthy subjects. However, there was significant heterogeneity among the studies regarding both hepcidin (I 2 = 98%, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.